Several chronic inflammatory pathologies are associated with dysregulated phosphorylation/activation of the NF-kB:IkB complex. Hence, preventing phosphorylation by …

IκB degradation reveals a nuclear localization sequence on NF-κB proteins (e.g., a p50-p65 heterodimer) allowing them to migrate to the nucleus, bind to specific κB-sites and regulate …

Pin1-mediated prolyl isomerisation of p65 leads to reduced IκBα binding, p65 nuclear accumulation, increased p65 stability and enhanced transcription [77,78]. Conversely, the …

NF-κB家族由P50、P52、P65、c-Rel和RelB五个成员组成。它们分别由NFKB1, NFKB2, RELA, REL和RELB基因进行编码。 每个成员都有一个N端Rel同源结构域（RHD），负责其与DNA …

p65 by acetylation appears to have a role in regulating its binding to nuclear IkBa. For example, deacetylation of p65 by HDAC3 promotes its binding to nuclear IkBa to result in an IkBa …

Jan 1, 2005 · Activation of NF-κB mainly occurs via IκB kinase (IKK)-mediated phosphorylation of inhibitory molecules, including IκBα. Optimal induction of NF-κB target genes also requires …

Jan 18, 2021 · IKK phosphorylates p65 on serine 536 within minutes following DNA damage, however in senescence a switch in phosphorylation from serine 536 to 468, and to recruitment …

Oct 30, 2018 · Hence, the NF-κB p65 signaling pathway has been a pivotal point for intense drug discovery and development. This review begins with an overview of p65-mediated signaling …

We have examined the possibility that IKK can phosphorylate the p65 NF-κB subunit as well as IκB in the cytokine-induced NF-κB activation. In the cytoplasm of HeLa cells, the p65 subunit …

This pathway relies on IKK- mediated IkappaB-alpha phosphorylation on Ser32 and 36, leading to its degradation, which allows the p50/p65 NF-kappa B dimer to enter the nucleus and activate …