Feb 22, 2021 · Rare cases of recurrent complete mole may be biparental (p57 +), resulting from mutations of maternal NLRP7 or KHDC3L, shutting down the entire maternal imprinting gene expression

Nov 2, 2021 · Evaluation of p57 expression should focus on 2 cell types, villous cytotrophoblasts and villous stromal cells, that show differential p57 expression (i.e., absence of staining in complete hydatidiform moles)

On immunohistochemistry (IHC) with p57, complete mole (CM) shows absent staining whereas hydropic abortus (HA) and partial mole (PM) show positive staining. This study was undertaken to evaluate the role of p57 IHC along with histomorphology in differentiating between CM, PM and non-molar or HA.

4 days ago · By immunohistochemistry, there is retained p57 expression in villous stromal cells and cytotrophoblasts. Molecular testing shows the presence of diandric triploidy. The findings are consistent with partial hydatidiform mole.

Oct 6, 2020 · Immunohistochemical analysis of p57 expression and molecular genotyping accurately subclassify molar specimens into complete hydatidiform mole (CHM) and partial hydatidiform mole (PHM) and...

We present a method for evaluating p57 antibodies (Abs) in hydatidiform mole (HM) and demonstrate the results for 4 p57 Abs in various cell types.

The present study attempted to find whether there is any role of p57 in differentiating PM and complete mole from the normal villous structure by immunohistochemical staining.

Feb 1, 2019 · This review discusses the differential diagnosis of hydatidiform moles, addresses the issue of diagnostic reproducibility for molar and non-molar specimens and importance of accurate diagnosis, explains the genetics of molar and non-molar specimens, illustrates the utility of p57 immunohistochemistry and DNA genotyping for improving diagnosis ...

Immunohistochemical analysis of p57 expression and molecular genotyping accurately subclassify molar specimens into complete hydatidiform mole (CHM) and partial hydatidiform mole (PHM) and distinguish these from nonmolar specimens.

Diagnostic utility Identification of complete hydatidiform mole. The histological differentiation of complete mole, partial mole and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid.