Sep 11, 2014 · Despite a relatively large body of evidence of the plant׳s chemical make-up, peer-reviewed studies to provide scientific information on physiological effects of Hoodia gordonii are relatively sparse. The role of the pregnane glycoside P57—commonly accepted to be responsible for appetite suppression—has been questioned recently.

Aug 4, 2020 · Hoodia, a succulent plant that grows in the Kalahari Desert, became popular for its purported appetite-reducing effects. It’s sold in tablet, tea, liquid extract, powder, and patch form to boost...

How Phenterdrene P57 works Anoretic (Appetite Suppressing) Effect: Changes levels of specific brain chemicals called neurotransmitters that can affect your appetite and allow a feeling of being full; therefore, helping you to eat less.*

Sep 5, 2024 · The active ingredient in Hoodia is the appetite-suppressing molecule, P57, or oxypregnane steroidal glycoside P57AS3. 3 In scarce clinical studies, P57 has been researched to evaluate its potential as an anti-obesity drug.

Hoodia is a cactus-type plant from the Kalahari Desert in Africa. People use hoodia to curb their appetite so they can lose weight. According to some claims, San bushmen in Africa eat hoodia …

Mar 19, 2025 · Explore the role of P57 in balancing body temperature and appetite through molecular mechanisms, genetic regulation, and key laboratory findings.

Herbal-based food supplements are widely used to treat obesity. Among them, the African cactiform Hoodia gordonii supplements are extremely popular. The development of Hoodia and P57, the purported active ingredient, has been problematic due to controversy about intellectual property rights and limited natural resources.

P57 is a diet supplement made from the chemical agents found in hoodia gordonii that have been chemically reproduced by U.S. pharmaceutical companies. It is used by people who want to lose weight and has been reported to cause hypophagia, decreased body weight, and resistance to a high-fat diet in animals.

The most commonly standardized compound in Hoodia Gordonii is known as P57, which is believed to be responsible for its appetite-suppressing effects. While there is no consensus on the optimal concentration of P57, it is generally recommended to choose products that contain a minimum of 20:1 concentration.

Mar 11, 2005 · P57 is supposed to be much more powerful than glucose as a signal to the hypothalamus to curb eating. In animal studies, hoodia reportedly suppressed rats’ appetite dramatically, and in a human trial, daily calorie intake among a group of obese volunteers who tested it dropped by 1,000 calories, even though they were encouraged to eat.