Feb 9, 2022 · As p53 loss of function may play a role in immunosuppression, we herein examine the effects of restoring p53 expression on the immune TME and ICB efficacy. We develop and …

We describe how the p53 mRNA affects post-translational modifications and the stability of the nascent protein as well as the expression of p53 isoforms with unique functions. Figure 1. Cell …

Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss …

TP53 gene encodes the transcription factor p53, one of the most important tumor suppressors. Under physiological conditions, p53 expression is tightly controlled and maintains a low level …

Dec 18, 2019 · Here, a redox-responsive nanoparticle (NP) platform is engineered for effective delivery of p53-encoding synthetic messenger RNA (mRNA). We demonstrate that the …

Here, a redox-responsive nanoparticle (NP) platform is engineered for effective delivery of p53 -encoding synthetic messenger RNA (mRNA). We demonstrate that the synthetic p53 -mRNA …

In a highly focused study, Fahreus and colleagues (Karakostis et al., 2019) describe how the interaction of p53 mRNA with the Mdm2 protein opens up new processes by which p53 …

Apr 23, 2019 · The role of the p53 mRNA as a target for signalling pathways illustrates how mRNA sequences have co-evolved with the function of the encoded protein and sheds new …

Aug 10, 2008 · Here we show that the p53 mRNA region encoding the Mdm2-binding site interacts directly with the RING domain of Mdm2. This impairs the E3 ligase activity of Mdm2 …

Feb 22, 2023 · The data show that the human p53 mRNA has evolved to respond to PERK-mediated regulation of mRNA structures in order to control p47 expression. The findings …