Jan 30, 2019 · The interplay between p53 and RAS signaling regulates cancer chemoresistance, but the detailed mechanism is unclear. In this study, we investigated the interactive effects of …

Mar 19, 2021 · We discover that cellular response to genotoxic stress cooperates with oncogenic Ras to activate JAK/STAT non-cell autonomously in the TME. Specifically, p53 is …

Our results reveal that Ras signaling induces cell proliferation by a mechanism that requires inactivation of the p53/p21 Cdk-interacting protein 1 (Cip1) axis by preventing acetylation of …

Mutant p53 increases expression of splicing regulator hnRNPK to promote inclusion of cytosine-rich exons within GTPase-activating proteins (GAPs), negative regulators of RAS family …

Mar 9, 2015 · Our results instead indicate that levels of the cyclin/Cdk inhibitor p21 protein are critical. The left panel shows how activated Raf, Mek, and Erk stimulate the activity of E2Fs by …

To investigate whether p53 is sufficient to induce senescence, we introduced a conditional murine p53 allele (p53val135) into p53 -null mouse embryonic fibroblasts and examined cell …

Oct 13, 2000 · While NIH-3T3 cells reveal a 12-fold induction of p53 transcriptional activity 4 hr after irradiation, their Ras-transformed counterparts show only a modest p53 response (4 …

May 10, 2022 · This study describes the functional kinomic landscape of Ras/p53 mutant chemically-induced squamous cell carcinoma in both the baseline unperturbed state and …

Feb 18, 2007 · Here we show that activated Ras V12 and loss of p53 function can cooperate to promote cell motility, a feature closely associated with cancer progression to malignancy.

Mar 14, 2010 · By knocking-down p53 or by expressing mutant p53, we revealed that p53 exerts its negative effect by at least two mechanisms mediated by its targets B-cell translocation …