Aug 13, 2021 · In this review, we summarize the gain of functions of p53-R175H in different cancer types, the interacting proteins of p53-R175H, and the downstream signaling pathways affected by p53-R175H to depict a comprehensive role of p53-R175H in cancer development.

Unlike wild-type p53, different states of p53 interact differently with the TME. most mutations in TP53 are missense mutations, such as the p53 R175H and R273H mutations. In addition to loss of tumor suppressor function, these mutants usually have gain-of-function activity and contribute to the malignant properties of cancer cells [ 9 ].

Jan 6, 2025 · We aimed to evaluate the in vitro and in vivo binding properties of two novel anti-p53 R175H monoclonal antibodies and to assess their performance as agents for molecular imaging. In vitro,...

Notably, p53 R175H acts as a repressor for ferroptosis by abrogating BACH1-mediated downregulation of SLC7A11 to enhance tumor growth; conversely, p53 R175H promotes BACH1-dependent tumor metastasis by upregulating expression of pro-metastatic targets.

Jul 15, 2024 · Using a novel iterative molecular docking-guided post-SELEX (systematic evolution of ligands by exponential enrichment) approach, we rationally engineer a high-performance DNA aptamer with improved affinity and specificity for p53-R175H.

Nov 16, 2009 · Results: We found that forced over-expression of p53-R175H significantly promoted cell migration and invasion, and induced activation of the epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-kinase (PI3K)/AKT pathway.

In this review, we summarize the gain of functions of p53-R175H in different cancer types, the interacting proteins of p53-R175H, and the downstream signaling pathways affected by p53-R175H to depict a comprehensive role of p53-R175H in cancer development.

Mar 27, 2023 · Notably, p53 R175H acts as a repressor for ferroptosis by abrogating BACH1-mediated downregulation of SLC7A11 to enhance tumor growth; conversely, p53 R175H promotes BACH1-dependent...

5 days ago · p53 mutant-dependent lipidome of pancreatic cancer cells. The two most common mutations in the p53 protein in human pancreatic cancer, R175H and R273H (equivalent to R172H and R270H in mouse), result in the expression of a stable mutant protein [27, 28].To test the regulatory role of these mutant p53 forms on the pancreatic cancer lipid profile, we carried out a global untargeted lipidomic ...

The p53 missense mutation p53 R175H (p53 R172H in mice) is a hotspot mutation in various cancer types. Therefore, monoclonal antibodies selectively targeting clinically relevant mutations like p53 R175H could prove immensely value.