Studies have shown that cells with p53 mutations have significantly lower levels of PUMA, making it a good candidate for a protein marker of p53 mutations, providing a simpler method for …

We have identified a novel gene named PUMA (p53 upregulated modulator of apoptosis) as a target for activation by p53. This gene encodes two BH3 domain-containing proteins (PUMA …

Jun 30, 2021 · Our data indicate that the p53 null allele completely rescues the mdm2 null lethality, while the puma null completely rescues the mdm2 null apoptosis but only partially …

PUMA (p53 upregulated modulator of apoptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2 family member and a critical mediator of p53-dependent and -independent apoptosis induced by a …

PUMA (p53 upregulated modulator of apoptosis) is a pro-apoptotic member of the BH3-only subgroup of the Bcl-2 family. It is a key mediator of p53-dependent and p53-independent …

Mar 1, 2001 · We have identified a novel gene named PUMA (p 53 u pregulated m odulator of a poptosis) as a target for activation by p53. This gene encodes two BH3 domain–containing …

Sep 25, 2003 · Our results demonstrate that Puma is a critical mediator of p53-induced cell death and actually accounts for nearly all of the apoptotic activity attributed to p53 in primary …

Feb 11, 2019 · High expression levels of PUMA are correlated with decreased mitochondrial pyruvate uptake and increased glycolysis in HCCs and poor prognosis of HCC patients. These …

Sep 9, 2005 · An unexpected stressful “jolt” to the cell, such as DNA damage or oncogene activation, results in a rapid increase of nuclear p53 and transcriptional activation of PUMA …

Jan 15, 2016 · Here we show the transcriptional activation of p53 stress responses in Mysm1−/− HSPCs. Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes …