The role of p53 in liver fibrosis - PMC - PubMed Central (PMC)
Here, we systematically discuss the regulation of p53 in different liver cells (hepatocytes, immune cells, HSCs, etc) and the role of p53 in the development of liver fibrosis, and propose possible …
p53 as a Dichotomous Regulator of Liver Disease: The Dose …
Mar 20, 2018 · Given that liver is a dynamic tissue with direct exposition to ingested nutrients, hepatic p53, by integrating cellular stress response, metabolism and cell cycle regulation, has …
p53-mediated redox control promotes liver regeneration and …
Oct 9, 2021 · Here, we show that p53 functions to support repair and recovery from CCl 4 -mediated liver damage, control reactive oxygen species (ROS) and limit the development of …
Liver p53 is stabilized upon starvation and required for amino acid ...
p53 protein in liver is stabilized under starvation. We previously reported the starvation-dependent induction of p53 target genes in several murine tissues relevant to metabolic homeostasis …
O -GlcNAcylated p53 in the liver modulates hepatic glucose ... - Nature
Aug 20, 2021 · More specifically, p53 binds to PCK1 promoter and regulates its transcriptional activation, thereby controlling hepatic glucose production. Mice lacking p53 in the liver show a …
p53 as a Dichotomous Regulator of Liver Disease: The Dose
Mar 20, 2018 · Given that liver is a dynamic tissue with direct exposition to ingested nutrients, hepatic p53, by integrating cellular stress response, metabolism and cell cycle regulation, has …
The role of p53 in liver fibrosis - PubMed
Oct 24, 2022 · The tumor suppressor p53 is the central hub of a molecular network, which controls cell proliferation and death, and also plays an important role in the occurrence and …
O-GlcNAcylated p53 in the liver modulates hepatic glucose
Aug 20, 2021 · More specifically, p53 binds to PCK1 promoter and regulates its transcriptional activation, thereby controlling hepatic glucose production. Mice lacking p53 in the liver show a …
The role of MDM2–p53 axis dysfunction in the hepatocellular
Jun 19, 2020 · To maintain long-term survival in hepatocytes, hepatitis viruses have lots of ways to destroy the defense strategies of hepatocytes by inducing TP53 mutation and silencing, …
p53 as a Dichotomous Regulator of Liver Disease: The Dose …
Given that liver is a dynamic tissue with direct exposition to ingested nutrients, hepatic p53, by integrating cellular stress response, metabolism and cell cycle regulation, has emerged as an …