Aug 24, 2023 · p53 ensures that cells repair any damaged DNA before cell division by inducing cell cycle arrest to allow time for DNA repair or to force the cell to undergo apoptosis via activation of BAX gene (J Biomed Biotechnol 2011;2011:603925, Cancers (Basel) 2018;10:135)

P53 immunohistochemistry has evolved into an accurate surrogate reflecting the underlying TP53 mutation status of a tumor, and has utility in the diagnostic workup of endometrial carcinomas.

Jun 25, 2022 · We aimed to comprehensively investigate abnormal p53 IHC patterns and their relation to clinicopathological and molecular features.

Oct 19, 2023 · To clarify the relationship between p53 immunohistochemistry (IHC) staining and TP53 alterations (including mutations and deletions) in large B-cell lymphomas (LBCLs) and to explore the possibility of p53 IHC expression patterns as surrogate markers for TP53 alterations.

Mutant pattern p53 IHC was observed in 63/63 (100%) serous carcinomas that were MMR-proficient/POLE exonuclease domain wild-type. Optimised p53 IHC performs well as a surrogate test for TP53 mutation in EC biopsies, demonstrates excellent inter-laboratory reproducibility, and has high clinical utility for molecular classification algorithms in ...

Mar 8, 2022 · Strong and diffuse immuno-expression of p53 by immunohistochemistry (IHC) is interpreted as a likely indicator of a TP53 gene mutation. We aimed to assess the p53 protein expression via IHC in NSCLC as a predictive biomarker of the response to ICIs.

2 days ago · While the haematoxylin and eosin stain remains the most powerful tool, p53 IHC is a valuable adjunct for determining and diagnosing dysplasia. Although p53 is helpful in predicting the risk of dysplasia in non-dysplastic Barrett's oesophagus, its sensitivity is low, limiting its routine use in this context.

Apr 7, 2025 · Salivary duct carcinoma (SDC) is an uncommon, high-grade malignancy. Identifying suitable prognostic factors is crucial for developing effective treatment strategies for SDC. p53 immunohistochemistry (IHC) is a potential prognostic marker for SDC. Traditionally, only the nuclear expression has been …

P53abn EC are POLE wildtype, mismatch repair proficient and show abnormal immunohistochemical (IHC) staining for p53. Correct interpretation of routinely performed p53 IHC has therefore become of paramount importance. We aimed to comprehensively investigate abnormal p53 IHC patterns and their relation to clinicopathological and molecular features.

Dec 5, 2022 · In the present study, we investigated the association between TP53 gene mutations and p53 immunohistochemical staining (IHC) patterns and non-genetic effect of MDM2 as a negative regulator of p53.