p53 regulates epithelial-mesenchymal transition and stem cell ...
This study elucidates a role for p53 in regulating EMT-MET (mesenchymal-epithelial transition) and stemness or differentiation plasticity, and reveals a potential therapeutic implication to …
Interplay between p53 and non-coding RNAs in the regulation of EMT …
Jan 4, 2021 · In this review, we present a detailed overview of miRNA/lncRNA-dependent mechanisms that control interplay between p53 and master-regulators of EMT and their …
PRMT1-p53 Pathway Controls Epicardial EMT and Invasion
Jun 6, 2020 · During heart development, the PRMT1-p53 pathway is required for epicardial invasion and formation of epicardial-derived lineages: cardiac fibroblasts, coronary smooth …
Loss of p53 epigenetically modulates epithelial to mesenchymal ...
Highlights • Loss of p53 confers aggressive mesenchymal phenotypes upon EMT induction in CRCs. • SATB1 shows agonistic relationship with EMT TFs SNAI1, SNAI2 and VIM with loss …
PRMT1-p53 Pathway Controls Epicardial EMT and Invasion
Jun 9, 2020 · Loss of PRMT1 leads to accumulation of p53 that enhances Slug degradation and blocks EMT. During heart development, the PRMT1-p53 pathway is required for epicardial …
Interplay between p53 and non-coding RNAs in the regulation of EMT …
Interestingly, p53 has been shown to mediate its effects via the miRNA-dependent mechanism that targets master-regulators of EMT, such as Zeb1/2, Snail, Slug, and Twist1. This regulation …
Mutant p53 gain-of-function induces epithelial–mesenchymal transition ...
Jul 30, 2012 · Here, we report that mutant p53 exerts oncogenic functions and promotes EMT in endometrial cancer (EC) by directly binding to the promoter of miR-130b (a negative regulator …
p53-Pirh2 Complex Promotes Twist1 Degradation and Inhibits EMT
By forming a complex with Twist1 and the E3 ligase Pirh2, wt p53 promotes the ubiquitination and proteasomal degradation of Twist1, thus inhibiting EMT and maintaining the epithelial …
PRMT1 regulates splicing of Mdm4 and decreases p53 stability, which enhances Slug degradation to block epicardial EMT. The PRMT1-p53 axis is required for epicardial invasion …
p53-Mediated PI3K/AKT/mTOR Pathway Played a Role in PtoxDpt-Induced EMT ...
May 5, 2019 · Epithelial-mesenchymal transition (EMT) involves metastasis and drug resistance; thus, a new EMT reversing agent is required. It has shown that wild-type p53 can reverse EMT …