p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often mutated in human cancers.

The tumor suppressor functions of p53 and its roles in regulating the cell cycle, apoptosis, senescence, and metabolism are accomplished mainly by its interactions with DNA. p53 works as a transcription factor for a significant number of genes.

Encoded by TP53, p53 acts primarily as a transcription factor, regulating gene networks involved in cell cycle arrest, DNA repair, apoptosis and senescence. p53’s versatility is reflected in its ability to respond to multiple cellular stresses, including DNA damage, hypoxia and nucleotide deficiency, thereby maintaining genomic stability by ...

May 2, 2016 · Already early in metazoan evolution, p53 started controlling the apoptotic demise of genomically compromised cells. p53 plays a prominent role as a facilitator of DNA repair by halting the cell cycle to allow time for the repair machineries to restore genome stability.

Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss key structural features of...

The central DNA binding domain (DBD) and the regulatory C-terminal domain (CTD) mediate the binding of p53 to DNA. The oligomerization domain (OD) is required for the formation of p53 tetramers, which is a prerequisite for p53 activity as a transcriptional activator. In addition, p53 has two transactivation domains (TAD1 and TAD2) ...

Jun 29, 2024 · Here, we synthesize recent and past studies on p53 decoding of DNA sequence, chromatin context, and cellular signaling cascades to elicit variable cell fates critical in human development,...

Model for allosterism of p53 DNA-binding sites and complementary conformations of the p53 protein. p53 conformations may critically determine interactions with components of coactivator/corepressor machinery, and chromatin remodeling and modifying complexes.

Mar 1, 2019 · Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological processes, including in DNA damage repair, cell cycle arrest, apoptosis and senescence.

Mar 28, 2024 · We learned that p53 is a DNA sequence-dependent transcription factor whose protein sequence comprises N-terminal transactivation domains and a central DNA binding domain (DBD) followed by an oligomerization domain and, at its extreme C terminus, a complex regulatory domain.