Jun 6, 2015 · A prominent downstream target of the CCNB1/cdk1 complex is the tumor suppressor p53, which restricts uncontrolled cell growth by inducing cell cycle arrest, mainly in G1, or apoptosis. Inhibition of CCNB1/cdk1 reactivated and …

Aug 23, 2010 · Enforced translocation of cyclin B1 and Cdk1 into mitochondria with a mitochondrial-targeting-peptide increased levels of Ser-315 phosphorylation on mitochondrial p53, improved ATP production and decreased apoptosis by sequestering p53 from binding to …

Jun 13, 2023 · The tumor suppressor p53, an important CDK1 substrate, plays critical roles in a diversity of physiologic functions by increasing genomic stability, inhibiting cell transformation, and initiating...

The transcriptionally active form of p53 triggers the expression of p21, which binds to and inhibits the Cdk2/cycE complex to prevent downstream protein phosphorylation required for passage into S phase. P53 is also known to control the G2/M checkpoint, by interacting with CDK1/cycB to arrest passage of cells from G2 into mitosis .

We found that inhibiting cyclin-dependent kinase 1 (CDK1) leads to activation of the DNA damage response, nuclear p53 stabilization, activation of a subset of p53 target genes including NOXA, and negative regulation of the anti-apoptotic protein MCL1 in human and mouse ESCs, but not differentiated cells.

Sep 9, 2017 · Taken together, we revealed that CDK1 and iASPP was up-regulated in CRC tissues and cell lines; CDK1 protein interacted with iASPP protein to affect CRC cell proliferation and apoptosis through p53 apoptosis pathway.

Jun 14, 2024 · Herein, we investigated whether p53 maintains the activation of the CDK1/cyclin B1 complex by regulating Wee1. We showed that p53 overactivation was accompanied by decreased Wee1 expression in ADR-stimulated podocytes, …

The phosphorylation of mitochondrial p53 by cyclin B1/Cdk1 stabilizes mitochondrial membrane potential and enhances mitochondrial ATP production, sequentially supplies the ATP required to repair damaged DNA and other critical cellular elements.

Nov 9, 2020 · CDKN1A, encoding for the CDK inhibitor p21CIP1, represents a critical target gene of p53/p73. Loss of p21CIP1 unleashes CDK1 activity which causes W-CIN in otherwise chromosomally stable cancer...

Apr 8, 2025 · In acute myeloid leukemia, Kojima et al. showed that inhibiting CDK1 increased p53-mediated mitochondrial apoptosis via Bax activation and the G2/M phase cell cycle arrest. Chen et al. provided evidence supporting the notion that the activation of p53 and p21 may effectively suppress the expression of CDKs, E2 Fs, and other factors that ...