May 6, 2004 · Here we identify the tumour-suppressor protein p53 as a COP1-interacting protein. COP1 increases p53 turnover by targeting it for degradation by the proteasome in a ubiquitin …

Our results indicate that COP1 regulates human breast cancer cell proliferation and apoptosis in a p53-dependent manner. These findings suggest that COP1 might be a promising potential …

Jun 29, 2023 · Overnutrition promotes PyMT mammary tumorigenesis via the CRL4 COP1 -p53 axis. The diabetes-cancer association remains underexplained. Here, we describe a glucose …

Jun 7, 2012 · The characterization of hypomorphic Cop1 mouse phenotypes provided evidence that COP1 targets JUN but not p53 for degradation in vivo and therefore acts as a tumour …

We also identified that 14-3-3σ, a p53 target gene product, interacted with COP1 and controlled COP1 protein stability after DNA damage. Mechanistic studies revealed that 14-3-3σ …

Oct 15, 2004 · Our analysis of both COP1 and p53 at the DNA, mRNA, and protein levels reveals that COP1 is overexpressed in breast and ovarian carcinomas suggesting that it may promote …

Nov 1, 2010 · In particular, COP1 has been shown to act as a negative regulator of p53 via ubiquitination . Given the significance of p53 and the altered expression of COP1 in human …

Dec 1, 2020 · Accumulated evidence has revealed that COP1 is involved in carcinogenesis via targeting its substrates, including p53, c-Jun, ETS, β-catenin, STAT3, MTA1, p27, 14-3-3σ, …

Oct 15, 2004 · We recently identified COP1 as a novel and critical negative regulator of p53. COP1 is a RING finger-containing protein that targets p53 for degradation to the proteasome …

Mar 7, 2018 · COP1 silencing resulted in p53 activation, which induced the expression of p21 and p53-upregulated modulator of apoptosis (PUMA) expression, and reduced the levels of cyclin …