Mar 31, 2022 · Induction of p53 leads to transcriptional downregulation of many cell cycle genes. The cyclin-dependent kinase inhibitor p21/WAF1/CIP1/CDKN1A is required for downregulation. RB-E2F complexes...

Nov 22, 2023 · Genome-wide transcriptome and interactome analysis reveals that RBM42 alters the expression of p53-regulated genes during DNA damage. Specifically, we demonstrate that RBM42 facilitates CDKN1A...

Mar 30, 2025 · Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity).

Jun 15, 2007 · We now show that p21 acts as a negative regulator of the cellular levels of p53. p21 knockdown by short hairpin RNA strongly increased p53 upregulation by a DNA-damaging drug doxorubicin in HT1080 fibrosarcoma cells.

Key elements of the beryllium-response were compared in normal and p53-knockdown A172 cells using RT-PCR and Western blotting. Results: In A172 cells, 10 μm BeSO 4 caused 300% increase in CDKN1A (cyclin-dependent kinase inhibitor p21) mRNA and 90% reduction of CCNE2 (cyclin E2) mRNA.

In this comprehensive review, we provide an overview of the multifaceted functions of CDKN1A/p21, present clinical data pertaining to cancer patients, and delve into potential strategies for targeting CDKN1A/p21 as a therapeutic approach to cancer.

p53-mediated Negative Regulation Is Dependent on the Expression of p21/CDKN1A—The requirement of a transactivation domain to repress survivin and stathmin prompted us to test whether a p53-induced gene product might mediate repression.

Sep 9, 2016 · 3.4. p53 is necessary for the up‐regulation of p21 in response to beryllium. The CDKN1A gene product, p21 Waf1/Cip1/Sdi1, is an important cyclin‐dependent kinase inhibitor that regulates cell cycle progression.

Nov 11, 2023 · CDKN1A expression is tightly regulated transcriptionally by p53. A delay in CDKN1A mRNA induction and p21 expression has been described for various stresses, such as UVC and during S-phase block with hydroxyurea (HU), despite comparable levels of RNA polymerase II and p53 at CDKN1A promoter to other stresses ( 19 , 20 ).

Nov 10, 2017 · p53 can induce cell cycle arrest at several stages, including G 1 /S and G 2 /M checkpoints. 1, 2, 3, 4 For example, it has been shown that p53 can induce G 1 arrest via...