p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is …

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of …

Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss …

p53 is an important tumour-suppressor protein that is altered in most cancers. p53 activates various responses, including cell-cycle arrest and apoptosis. Each of these appears to …

TP53 is the most commonly mutated gene in human cancer with over 100,000 literature citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a history …

p53′s tumor-suppressive activity has been found to limit tumor cell proliferation not only within cells but also in the extracellular space. Thus, the loss of p53 has a profound impact on the …

p53 inhibits the NF-κB pathway thereby suppressing the expression of cytokines and chemokines and reducing the accumulation of ROS. p53 mutant proteins can participate in the cGAS …

Mar 28, 2024 · We describe here the paradox of how, depending on its mutational status in cancer, p53 can be both a tumor suppressor and an apparent oncogene. The major challenge …

Mar 1, 2019 · Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological processes, including in DNA damage repair, cell cycle arrest, apoptosis and …

May 9, 2024 · p53 plays a central role in suppressing tumorigenesis. In this issue, Liu et al. review the complexity of different layers of p53 regulation, and the recent advance of the p53 pathway …