VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent …
May 1, 2024 · We demonstrated that VGLL2-NCOA2 and TEAD1-NCOA2-controlled transcriptional activation is YAP/TAZ-independent, and these fusion proteins specifically …
Mechanosensation to inflammation: Roles for YAP/TAZ in innate
May 2, 2023 · Here, we shed light on the associations between YAP/TAZ and inflammatory epigenetic proteins, such as the histone acetyltransferase (HAT) p300 and the histone …
EP300 promotes lung cancer cell proliferation by regulating the ...
Jan 15, 2024 · In this study, we found that EP300, one histone acetyltransferase, interacted with YAP and was recruited into the phase separated condensates of YAP. Transcriptomic analysis …
YAP/TEAD–Mediated Transcription Controls Cellular Senescence
Jun 13, 2013 · Recently, it has been reported that the downregulation of p300/CBP–mediated chromatin-dependent alteration of S-phase progression defect induces cellular senescence …
PXR triggers YAP-TEAD binding and Sirt2-driven YAP ... - PubMed
Mechanistically, PXR activation significantly decreased YAP acetylation, which was interrupted by the sirtuin inhibitor nicotinamide (NAM). In addition, p300-induced YAP acetylation contributed …
Tea domain transcription factor TEAD4 mitigates TGF-β signaling …
TEAD4 associates with activated Smads in the nucleus in a YAP/TAZ-independent manner and, consequently, attenuates the binding of p300 to Smads and interferes with TGF-β signaling …
LPCAT3 Is Transcriptionally Regulated by YAP/ZEB/EP300 and …
Sep 14, 2023 · E1A-binding protein p300 (EP300) simultaneously bound with YAP and ZEB, and induced H3K27Ac for LPCAT3 transcription. This mechanism was verified in primary LUAD …
2024年6月28日 刘仕杰：YAP acetylation in cardiac regeneration
Jun 19, 2024 · Here we show P300/CBP acetylates YAP in the nucleus, and SIRTs deacetylate YAP in response to the metabolic stresses. In MI cardiomyocytes, YAP acetylation increases …
VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent
Jul 1, 2024 · We demonstrated that VGLL2-NCOA2 and TEAD1-NCOA2-controlled transcriptional activation is YAP/TAZ-independent, and these fusion proteins specifically engage the …
JCI - Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in …
May 30, 2019 · RNA sequencing and reverse transcription PCR identified highly recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poromas (92/104 lesions, 88.5%) and their rare …