Oct 1, 2007 · As a cyclin-dependent kinase inhibitor, p16 INK4a plays a key role in cell cycle progression and cellular differentiation, and its expression is frequently altered in human …

While ectopic expression of P300 is able to induce cell cycle arrest through up-regulating p16 expression, the participation of P300 in p16 transcription is Sp1-dependent.

In general, our study found increased expressions of p16 and p300 in peripheral blood EPCs of COPD patients, and CSE would lead to the increase of p16. In addition, p300/Sp1 enhanced …

Mar 20, 2008 · In this report, we demonstrate that p300 was able to induce cell cycle arrest, and this process was reversed by p16(INK4a) silencing by RNA interference in HeLa cells. We …

Another factor involved in p16 activation is p300 that contains histone acetylase activity and an interaction motif for Sp1 [88, 89]. Wang et al showed that the interaction between p300 and …

Oct 22, 2021 · Acetyltransferase p300, a major epigenetic writer of acetylation on histones and transcription factors, contributes significantly to modifications of chromatin landscape of genes …

Oct 3, 2011 · Our data showed that HBP1 interacted with histone acetyltransferase p300 and CREB-binding protein (CBP) and also recruited p300/CBP to p16 INK4A promoter. HBP1 was …

Sep 13, 2011 · Here we show that downregulation of p300 histone acetyltransferase activity induces senescence by a mechanism that is independent of the activation of p53, p21CIP1 …

present evidence that p300 participated in Sp1-mediated p16 transcription, and discuss the possible mechanism of the functional interaction between Sp1 and p300 in p16 transcriptional...

Aug 19, 2021 · Here, we are trying to explore whether the high expression of p16 mediated by p300/Sp1 can cause chronic obstructive pulmonary disease through promoting the …