The p300-CBP coactivator family in humans is composed of two closely related transcriptional co-activating proteins (or coactivators): p300 (also called EP300 or E1A binding protein p300) CBP (also known as CREB-binding protein or CREBBP)

Mar 20, 2007 · CREB-binding protein (CBP) and its homologue p300 are transcriptional co-activators of various sequence-specific transcription factors that are involved in a wide array of cellular...

Jun 8, 2021 · Recent efforts have identified specific and potent CBP/p300 inhibitors that target the acetyltransferase activity and the acetytllysine-binding bromodomain (BD) of CBP/p300. These compounds inhibit AR signaling and tumor growth in prostate cancer.

Aug 1, 2001 · Phosphorylation of CREB family members promotes target gene expression through the recruitment of the coactivator CREB-binding protein (CBP) and its paralogue p300.

CREB-binding protein (CREBBP) and E1A-binding protein P300 (EP300) are two key acetyltransferases and transcriptional cofactors that regulate gene expression by regulating the acetylation levels of histone proteins and non-histone proteins.

CBP and p300 both contain a consensus protein kinase A (PKA) site adjacent to their third zinc finger domains, and several groups have proposed that phosphorylation by PKA may contribute to CBP/p300 regulation.

CBP (CREB-binding protein) and p300 are versatile coactivators that link transcriptional activators to the basal transcriptional apparatus. In the present study, we identify CBP and p300 as coactivators of the nuclear factor-κB (NF-κB) component p65 (RelA).

Feb 1, 2000 · Recently, 2 highly related and widely expressed molecules, CREB-binding protein (CBP) and p300, have emerged as important cofactors for a broad number of transcription factors both within and outside the hematopoietic system.

The CREB-binding protein (CBP) and p300 are paralogous lysine acetyltransferases that serve as critical co-activators for transcription factors involved in diverse signaling pathways in cancer. Work in the last two decades has firmly established CBP and p300 as important regulators of nuclear hormone signaling mediated by nuclear receptors ...

Jul 20, 2020 · The transcription coactivators CREB binding protein (CBP) and p300 are highly homologous acetyltransferases that mediate histone 3 lysine 27 acetylation (H3K27ac) at regulatory elements such as enhancers and promoters.