The Consolidated P2Y was an American sesquiplane maritime patrol flying boat. The aircraft was also made by Martin as the P3M, as a parasol monoplane, due to the Navy awarding production contracts separately from prototype contracts.

P2Y receptors mediate responses including vasodilation, [2] blood clotting, [3] and immune response. [4] Due to their ubiquity and variety in function, they are a common biological target in pharmacological development.

P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene. [5] [6] The product of this gene, P2Y 2 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides.

Dopaminergic neurons in the substantia nigra pars compacta in an adult rat express P2X (P2X 1, P2X 2, P2X 3, P2X 4, P2X 5, P2X 6) and P2Y (P2Y 1, P2Y 4, P2Y 6, P2Y 14) receptors. Astrocytes within this region express the P2Y 2 receptor, whereas microglial cells …

With the advent of AR-C118925, a selective and potent P2Y 2 R antagonist that became commercially available only a few years ago, new opportunities exist to gain a more robust understanding of P2Y 2 R function and assess therapeutic effects of P2Y 2 R antagonism.

Mar 15, 2022 · Overall, current research suggests that P2Y receptors in the CNS regulate repair mechanisms that are triggered by tissue damage, inflammation and disease and thus P2Y receptors represent promising targets for the treatment of neurodegenerative diseases. Keywords: Neuroinflammation, P2Y receptor, P2Y receptor agonist, P2Y receptor antagonist.

This review discusses the characteristics of P2Y 2 R that make it unique among P2 receptors, namely its involvement in five distinct signaling pathways including canonical Gα q protein signaling. We also discuss the effects of other P2Y 2 R antagonists and the pivotal development of AR-C118925.

Mar 30, 2025 · P2RY2 (Purinergic Receptor P2Y2) is a Protein Coding gene. Diseases associated with P2RY2 include Dry Eye Syndrome and Cystic Fibrosis. Among its related pathways are Purinergic signaling and Response of endothelial cells to shear stress.

P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). P2Y receptors are widely expressed and play important roles in physiology and pathophysiology.

P2Y receptors are directed to discrete regions of cells that express multiple subtypes. Most cell types express more than one P2Y receptor subtype. At the peptide level, P2Y receptors show a low level of sequence homology, notably over the region delimited by TM1 to TM7 where they are only 19-55% identical.