Dynamic tracking of p21 mRNA in living cells by sticky-flares for …
Feb 3, 2022 · Monitoring the expression level of the intracellular tumor suppressor gene p21 mRNA is essential to reveal the progress and prognosis of a tumor. Methods widely reported …
RBMS2 inhibits the proliferation by stabilizing P21 mRNA in …
Dec 4, 2018 · RBMS2 stabilized the mRNA of P21 by directly binding to the AU-rich element of 3′-UTR region. Anti-proliferation activity induced by overexpression of RBMS2 was rescued by …
cyclin-dependent kinase inhibitor p21 is regulated by RNA …
Sep 3, 2010 · We found that PCBP4 expression decreases cyclin-dependent kinase inhibitor p21 induction in response to DNA damage. We also provided evidence that PCBP4 regulates p21 …
p21 in Cancer Research - PMC
Aug 14, 2020 · These studies point out the complexity of p21 in cancer therapy and the importance of combined therapeutic approaches. p21 deficient mouse mammary tumor virus …
An update on long intergenic noncoding RNA p21: a regulatory …
LincRNA - p21, also called as TRP53COR1 (P53 Pathway Corepressor 1 protein tumor), is a new lncRNA that has an important function in initiating and progressing various cancers. Moreover, …
Multifaceted p21 in carcinogenesis, stemness of tumor and tumor …
Ducos K, Panterne B, Fortunel N, Hatzfeld A, Monier MN, Hatzfeld J. p21 (cip1) mRNA is controlled by endogenous transforming growth factor-beta1 in quiescent human hematopoietic …
Splicing factor SRSF3 represses translation of p21cip1/waf1 mRNA
Nov 7, 2022 · Our study proposes a model in which SRSF3 regulates translation by interacting with eIF4A1 at the 3'UTR region of p21 mRNA. We also found that SRSF3 localizes to the …
HuR regulates p21 mRNA stabilization by UV light - PubMed
Our findings indicate that HuR plays a major role in regulating stress-induced p21 expression by enhancing p21 mRNA stability and that these effects are coupled to HuR's elevated presence …
Demystifying the mechanistic and functional aspects of p21 gene ...
Sep 17, 2016 · To determine whether dsP21-322-mediated p21 expression occurs at the transcriptional level, we designed a primer set to introduce an intron in the p21 pre-mRNA, …
Examination of the expanding pathways for the regulation of p21 …
Jul 1, 2010 · Under non-stressed conditions, p21 is expressed at low levels and promotes cell cycle progression. Under stress conditions, p21 expression is increased through p53 …