p21 Regulates Wnt-Notch balance via DREAM/MMB/Rb-E2F1 and …
Sep 28, 2024 · In this study, we elucidate the mechanisms by which p21 links the Wnt-Notch pathway with the DREAM/MMB/Rb-E2F1 pathway, and explore how this interaction may …
p21 Regulates Wnt-Notch balance via DREAM/MMB/Rb-E2F1 and …
Sep 28, 2024 · The overexpression of p21 rescued the DREAM pathway, as well as the imbalance of Wnt-Notch pathway. In summary, our data identify p21 as an important factor in …
Induction of Wnt signaling antagonists and p21-activated kinase ...
Our analyses indicated that p21-activated kinase 2 (Pak2) is induced at regenerating CMs, where it phosphorylates cytoplasmic β-catenin at Ser 675 and increases its stability at disassembled …
The overexpression of p21 rescued the DREAM pathway, as well as the imbalance of Wnt-Notch pathway. In summary, our data identify p21 as an important factor in maintaining sequential...
p21-Activated kinase interacts with Wnt signaling to regulate …
We found that pak-1/Pak (p21-activated kinase), along with putative activators of Pak, nck-1/Nck, and ced-10/Rac, regulates P7.p polarity. Mutations in these genes suppress the polarity defect …
Wnt/β-Catenin Signaling Induces the Aging of Mesenchymal Stem …
In summary, our study indicates the Wnt/β-catenin signaling may play a critical role in MSC aging induced by the serum of aged animals and suggests that the DNA damage response and …
p21CIP1 Promotes Mammary Cancer-Initiating Cells via Activation of Wnt ...
TCF1 knockdown in PyMT cells suppressed tumorsphere formation due to Cyclin D1 attenuation. These data demonstrate that p21 promotes a CSC-like phenotype via activation of …
GEO Accession viewer - National Center for Biotechnology …
Dec 10, 2023 · The overexpression of p21 rescued the imbalance of Wnt-Notch pathway. Our data identify p21 as an important factor in maintaining sequential mobilization, proliferation, …
A WNT/p21 Circuit Directed by the C-Clamp, a Sequence-Specific …
Our results indicate that a rapid-response WNT/p21 circuit is driven by C-clamp target gene selection. Overactive Wnt signaling is causally linked to carcinogenesis in many different …
p21-Activated kinase interacts with Wnt signaling to regulate …
Sep 9, 2012 · In Caenorhabditis elegans, Wnt signaling regulates the anterior/posterior polarity of the P7.p vulval lineage, and mutations in lin-17/Frizzled cause loss or reversal of P7.p lineage …
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