Here, we report that the cell cycle inhibitor p21 places cells under immunosurveillance to establish a biological timer mechanism that controls cell fate. p21 activates retinoblastoma protein (Rb) …

Through this approach, we identified p21 (Cdkn1a), which encodes the cyclin-dependent kinase (CDK) inhibitor p21, and conducted an in-depth analysis of its functions from the time cells first …

Trop-2 is a novel target for ADC therapy because of its high expression by many solid cancers. The rational development of IMMU-132 represents a paradigm shift as an ADC that binds a …

Among those genes whose expression is highly upregulated during stress is the cyclin-dependent kinase inhibitor p21, which plays an important role in regulating cell growth (12,24,40). An …

Here, we report that the cell-cycle inhibitor p21 places cells under immunosurveillance to establish a biological timer mechanism that controls cell fate. p21 activates retinoblastoma protein …

Here we show that the cell-cycle regulator p21 is involved in immune system function. T lymphocytes from p21 −/− mice exhibit significant proliferative advantage over wild-type cells …

Mar 31, 1999 · Nonspecific antisera, cyclin A, and p21 immunoprecipitates were assayed for both histone H1 kinase activity and cyclin A, Cdk2, and p21 content as described in Materials and …

Following anti-mitogenic signals or DNA damage, p21 and p27 bind to cyclin–CDK complexes to inhibit their catalytic activity and induce cell-cycle arrest. Interestingly, recent discoveries …

Oct 29, 2021 · Here, we report that the cell-cycle inhibitor p21 places cells under immunosurveillance to establish a biological timer mechanism that controls cell fate. p21 …

Sep 1, 1996 · In the present study, the authors immunohisto- chemically stained p21 and p53 proteins in formalin- fixed, paraffin-embedded sections of human colorectal cancers to …