Here we report the design of a peptidergic compound, Ac-DGGLAG-NH2, called P21, when administered peripherally, enhanced learning as well as both short-term and spatial reference memories of normal adult C57Bl6 mice.

p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4 /6 complexes, and thus functions as a regulator of cell cycle progression at G 1 and S phase.

Dec 11, 2024 · This International Conference on Harmonization (ICH) guidance provides a unified standard for the European Union, Japan, and the United States to facilitate the mutual …

Following anti-mitogenic signals or DNA damage, p21 and p27 bind to cyclin–CDK complexes to inhibit their catalytic activity and induce cell-cycle arrest. Interestingly, recent discoveries suggest that p21 and p27 might have new activities that are unrelated to their function as CDK inhibitors.

Oct 23, 2020 · Cell cycle cdk inhibitor p21CIP1 has a central and paradoxical role in the regulatory crossroads leading to senescence, apoptosis, or differentiation. p21 is an essential target of tumor...

The inhibitory effect of P21 on cell cycle progression correlates with its nuclear localization. P21 can be induced by both p53-dependent and p53-independent mechanisms. Some other important functions attributed to p21 include transcriptional regulation, modulation or inhibition of apoptosis.

The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) is unique in bringing together the regulatory authorities and pharmaceutical industry to discuss scientific and technical aspects of …

由于p21是p53肿瘤抑制因子的转录靶点，由于基因毒性应激暴露，p21在含有稳定p53的细胞中表达增加。 在所有成人组织中都有表达，在大脑中表达水平降低5倍。 由p53/TP53、mezerin (抗白血病化合物)和IFNB1激活其表达。 被HDAC1抑制表达。 通常细胞核定位。 细胞质（通过PIM1磷酸化p21 Thr-145导致p21向细胞质转移，增强了p21蛋白的稳定性）。 图二：p21靶点ICC实验结果图，Anti-p21产品 (ab109520)。 蓝色：DAPI；红色：alpha Tubulin；绿色：p21。 …

Cytoplasmic p21 conveys an anti-apoptotic function in many tumor cells through its induction by the DNA damage responsive p53 pathway, such that attenuation of p21 sensitizes cancer cells to DNA-damaging chemotherapy.

Nov 3, 2023 · In the present study, we examined the immuno-histochemical (IHC) expression of p21 as a novel marker of liver metastases in primary PET tissues and defined the most optimal cut-off of p21 IHC score to differentiate clinically indolent and aggressive primary PETs.