The senescence-associated secretory phenotype and its ... - Nature
Apr 23, 2024 · Upregulation of the cyclin-dependent kinase (CDK) inhibitors p21 and p16 are common features of senescent cells, and their inhibition of CDK4 and CDK6 leads to the …
Inhibition of the IL-6 signaling pathway: A strategy to combat …
Apr 1, 2013 · IL-6, a phosphorylated glycoprotein of a molecular weight of 26 kDa, is a T cell-derived B cell stimulating factor. The cDNA encoding IL-6 was cloned and reported by Hirano …
IL-6 and Matrix Metalloproteinase-1 Are Regulated by the Cyclin ...
Jan 15, 2003 · Analyses of p21-deficient mouse synovial fibroblasts reveal a 100-fold increase in IL-6 protein and enhance IL-6 and MMP-3 mRNA. Restoration of p21, but not overexpression …
Targeting p21‐Positive Senescent Chondrocytes via IL‐6R/JAK2 …
Jan 23, 2025 · Our findings indicate that IL-6 drives the activation of the p53/p21 pathway by downregulating SIRT1, thereby inducing cellular senescence. Additionally, the IL-6/sIL-6R …
Targeting p21-Positive Senescent Chondrocytes via IL-6R/JAK2
Jan 25, 2025 · This study investigates the role of interleukin-6 receptor (IL-6R) in mediating IL-6 signaling and its contribution to OA progression. Here, significantly elevated IL-6R expression …
SPI1 activates mitochondrial unfolded response signaling to inhibit ...
12 hours ago · c IL-6, IL-8, and TNF-α levels in ... P21 and MMP13 in both the 13.5 N + AAV-SPI1 and the 13.5 N + AAV-PERK groups was markedly lower than that in the control group. The ...
IL-6 and matrix metalloproteinase-1 are regulated by the cyclin ...
Jan 15, 2003 · Analyses of p21-deficient mouse synovial fibroblasts reveal a 100-fold increase in IL-6 protein and enhance IL-6 and MMP-3 mRNA. Restoration of p21, but not overexpression …
IL-6 modulates hepatocyte proliferation via induction of …
Dec 30, 2005 · Our findings suggest that IL-6 directly inhibits hepatocyte proliferation via a p21cip1-dependent mechanism and indirectly enhances hepatocyte proliferation via …
p21-activated kinase 1 determines stem-like phenotype and …
Collectively, these data indicate that sunitinib-induced stem-like phenotype in vivo could be attributed, at least in part, to PAK1/NF-κB/IL-6 activation and that simultaneous PAK1/NF …
Hesperidin inhibits lung fibroblast senescence via IL-6/STAT3 …
Apr 1, 2023 · We demonstrated that hesperidin could alleviate bleomycin-induced pulmonary fibrosis in mice. The expression level of senescence marker proteins p53, p21, and p16 was …