Oct 31, 2017 · We found that, during trophoblast fusion, the cell-cycle inhibitor p21 interacted with the GCM1 transcription factor, and this complex bound to the promoter of Syncytin-2 and …

Oct 31, 2017 · Given that p21-positive mononucleated cells are Ki67-negative in the human placenta, our data suggest that GCM1 may induce p21 expression to arrest the cell cycle, and …

Mar 20, 2017 · Here, using live single-cell measurements of p21 protein in proliferating cultures, we show that naturally occurring DNA damage incurred over S-phase causes p53-dependent …

Nov 1, 2008 · Glial cell missing homolog 1 (GCM1) is an important transcription factor regulating placental cell fusion. Recently, we have demonstrated that GCM1 is a labile protein and that …

Aug 27, 2021 · In fact, our data revealed that the fusion-related genes HERV-FRD (syncytin-2), CGbeta5 (β-hCG), and GCM1 were reduced upon p21 depletion. Importantly, decreased p21 …

Mar 6, 2017 · Upon DNA damage or other stressors, the tumor suppressor p53 is activated, leading to transient expression of the cyclin-dependent kinase inhibitor (CKI) p21. This either …

Co-immunoprecipitation analyses showed that p21 interacted with GCM1 ( Figure 4 G). A FluoPPI (fluorescent-based technology detecting protein-protein interactions) assay, in which PPIs are...

Aug 10, 2024 · In our study, the cell cycle-related gene CDKN1A (p21) was identified as upregulated in cell fusion and downregulated following CTGF overexpression. p21 is one CKI …

Overexpression of Syncytin-2 overrides cell-cycle restriction and results in functionally compromised syncytia carrying mitotic features. p21 coordinates with transcription factor …

GCM1 interacts with other proteins important for trophoblast differentiation, such as p21, DLX3, and CREB/CBP, and promotes expression of numerous genes associated with ST formation, …