This nuclear retention, which strictly depends on association with endogenous p21, prevents activation of cyclin B1-Cdk1 by Cdc25 and Cdk-activating kinase as well as its recruitment to …

Mar 31, 2022 · Here, their functional interaction through the cyclin-dependent kinase inhibitor p21/CDKN1A is described. The resulting p53-p21-RB mechanism controls transcription of a …

Cyclin B1-Cdk1 complexes are maintained in an inactive state by association with p21, which provokes nuclear retention of cyclin B1-Cdk1 and prevents their activation at the centrosome …

Aug 2, 2016 · The multifunctional protein p21Cip1/CDKN1A (p21) is an important and universal Cdk-interacting protein. Recently, we have reported that p21 is involved in the regulation of the …

Non-phosphorylatable p21 binds strongly to Cdk1/cyclin B1. To gain insight into the binding affinity of p21 and its mutants to Cdk1/cyclin B1, pulldown assays were performed using …

CDK1, at least in some tissues, may be the crucial target of p21 in tumorigenesis 27 because p21 effectively inhibits the kinase activity of CDK1 both in unstressed cells and after genotoxic …

Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein. p21 …

Jun 1, 2016 · Cyclin-dependent kinase (CDK) inhibitor p21 (also known as p21 WAF1/Cip1) is one of these factors that promote cell cycle arrest in response to a variety of stimuli. The …

The cell cycle inhibitor p21(CDKN1A) is a protein playing multiple roles not only in the DNA damage response, but also in many cellular processes during unperturbed cell growth. The …

Jun 4, 2004 · The critical role of p21 in nuclear sequestration and blocking activation of cyclin B1-Cdk1 is underscored by our results showing that exposure of p21-deficient or null fibroblasts to …