Oral administration: Gavage (PO); procedure refer to Oral Gavage in Mice and Rats Inhalant and nasal administration: Intranasal (IN) refer to Intranasal Instillation in Rodents, and Intratracheal (IT)

Feb 28, 2022 · In mice, volumes less than 35µl have been reported to be distributed primarily to the upper respiratory tract, whereas a 50 µl volume was predominantly deposited in the lower respiratory tract.

Per os (PO): Administering substances by mouth. Gavage: Administering substances via a tube passed through the nose or mouth into the esophagus or stomach. Rectal: Administering substances into the rectum.

We compared alternative routes for 18 F-fluorodeoxyglucose (FDG) administration, such as the retroorbital (RO), intraperitoneal (IP) and per oral (PO) routes, with the intravenous (IV) route in normal tissues and tumors of mice.

In an elegant study conducted in mice, Sumbria and colleagues investigated plasma and brain availability of IgG-TNF Decoy Receptor Fusion Protein (MW = 210 kDa) after IV, IP and SC administration at 0.7, 3 and 10 mg/kg doses .

Administration of substances to laboratory animals requires careful consideration and planning to optimize delivery of the agent to the animal while minimizing potential adverse experiences from the procedure. For all species, many different routes are …

Oral gavage (dosing) is used when a specific volume of an agent needs to be administered orally. Whenever possible, alternatives such as purchasing custom-made chow containing the experimental agent or dosing with a water bottle should be considered.

Jun 10, 2022 · 1.1. Oral administration (po) • Drug circulation route: esophagus → stomach → small intestine → small intestinal capillaries (absorption into blood) → jejunal vein → superior mesenteric vein → hepatic portal vein → liver → hepatic vein → inferior vena cava → right atrium → right ventricle absorption into the blood ...

Oral Route (PO) • If accuracy of PO dosing is very important, liquids should be administered by gavage. This technique is associated with potential adverse consequences and requires extensive experience. At CoMed, gavage is mainly performed by the animal technicians, but the

Results: We have studied the PO treatments efficacy on reduction of body weight (BW) and glucose tolerance ability in 221 mice of 13 different CC lines as a response to two different diets: the...