The positive transcription elongation factor, P-TEFb, is a multiprotein complex that plays an essential role in the regulation of transcription by RNA polymerase II (Pol II) in eukaryotes. [1] …

Feb 2, 2023 · The positive transcription elongation factor b (P-TEFb) is composed of cyclins T1 or T2 and cyclin-dependent kinase 9 that regulate the elongation phase of transcription by RNA …

In this review article, I will summarize our knowledge about basic P-TEFb functions, the regulatory mechanism of P-TEFb-dependent transcription, P-TEFb’s involvement in biological processes …

May 8, 2018 · Three major positive transcription elongation factor b (P-TEFb)-containing complexes have been identified in mammals: 7SK small nuclear ribonucleoprotein–P-TEFb …

Escape from the action of N-TEF requires the action of at least one positive transcription elongation factor (P-TEF), eventually identified as P-TEFb (52). P-TEFb allows the transition …

Sep 2, 2009 · Among them, transcription elongation is positively regulated by the positive transcription elongation factor b (P-TEFb), consisting of CDK9 and cyclin T1, T2 or K. P-TEFb …

Escape from the action of N-TEF requires the action of at least one positive transcription elongation factor (P-TEF), eventually identified as P-TEFb (52). P-TEFb allows the transition …

The positive transcription elongation factor b (P-TEFb) is a cyclin-dependent kinase that controls the elongation phase of transcription by RNA polymerase II (RNAPII). This process is made …

P-TEFb, a heterodimer of cyclinT1 and the kinase CDK9, plays a pivotal role in enhancing transcription from the 5′LTR (Wei et al., 1998). Because of its prominent role in controlling …

By antagonizing negative elongation factors and phosphorylating the C-terminal domain of RNA polymerase II, P-TEFb facilitates the elongation and co-transcriptional processing of nascent …