An orexin receptor antagonist, or orexin antagonist, is a drug that inhibits the effect of orexin by acting as a receptor antagonist of one (selective orexin receptor antagonist or SORA) or both …

Orexin receptors are particles on membranes of orexin neurons that initiate intracellular action to promote a state of wakefulness, when stimulated by orexin. Orexin antagonists bind to orexin …

May 13, 2022 · Orexin receptor antagonists are a novel class of sedative-hypnotics for sleep-onset and sleep-maintenance insomnia, and currently three agents have been approved by …

Dec 22, 2023 · Dual orexin receptor antagonists (DORAs) are a new type of prescription sleep aid that targets the body’s orexin system. These medications work by acting as orexin receptor …

Feb 21, 2025 · Orexin receptor antagonists are used to treat insomnia. These medications work by blocking the action of orexin, a chemical in your brain that helps regulate wakefulness and …

In this review article, the potential of orexin receptor antagonists—primarily dual orexin receptor antagonists (DORAs)— is discussed as an additional pharmacological option for treatment of …

Some orexin receptor antagonists have been designed and researched for the treatment of insomnia in rats, dogs and humans (Brisbare-Roch et al., 2007), including two categories: …

We discuss the actions of orexin receptor antagonists, including selective OX1R antagonists (SORA1s), selective OX2R antagonists (SORA2s), and dual OX1/2R antagonists (DORAs), in …

Orexin antagonists, especially those that block OX2 or both OX1 and OX2 receptors, clearly promote sleep in animals, and clinical results are encouraging: Several compounds are in …

Sep 14, 2024 · Dual orexin receptor antagonists (DORAs) have been investigated as a treatment for chronic insomnia. The objective of this systematic review was to examine evidence for two …