Herein, we describe a transgenic porcine model—the Oncopig Cancer Model (OCM)—as a next-generation large animal platform for the study of hematologic and solid tumor oncology.

Aug 23, 2017 · Herein, we describe a transgenic porcine model-the Oncopig Cancer Model (OCM)-as a next-generation large animal platform for the study of hematologic and solid tumor oncology.

The Oncopig is a transgenic pig that develops site/cell specific tumors following adenovirus mediated Cre recombinase (AdCre) exposure. As an HCC model, the OCM was designed to manifest those mutations most commonly found in >50% of human cancers, namely P53(R167H) (a defining HCC oncogenesis event) and KRAS (G12D).

Jan 29, 2024 · Pigs share close similarities to humans and may serve as an alternative model. Recently, a transgenic ‘Oncopig’ line has been generated to induce solid tumors with organ specificity, opening the potential of Oncopigs as a platform …

Jul 1, 2015 · The pig has many attributes that make it an ideal platform to develop a genetically defined, large animal model of cancer. We now report the creation of a transgenic oncopig line encoding a Cre recombinase inducible transgene encoding KRAS G12D and TP53 R167H, a commonly mutated oncogene and tumor suppressor , respectively, in human cancers.

Jul 1, 2015 · To create an inducible porcine model of cancer, which we term “oncopig”, we first cloned the porcine KRAS and TP53 cDNAs from the Duroc pig (2–14, TJ Tabasco) that was used to sequence the pig genome .

In this article, we will briefly highlight the advantages and considerations for use of pigs for cancer research and summarize representative examples of the use of pig models in cancer research. Figure 1. Advantages and disadvantages of using small and large preclinical cancer models.

Feb 11, 2019 · Mutations to genes like P53 and KRAS, two of the most commonly mutated oncogenes founds in human cancers. The answer that he, and others that are picking up the pig, are discovering, is ‘Yes.” A...

Given a number of limitations of rodent-based cancer models, coupled with the fact that pigs share many genetic and physiological similarities with humans, we investigated the potential of developing genetic porcine models of cancer.

Feb 18, 2025 · Pigs represent an ideal platform that provide both regulatory acceptable and clinically relevant large animal cancer models due to their similar physiology, size, genetics, immunity, and metabolism in relation to humans. The Oncopig bladder cancer model is an ideal tool for testing endoscopic and other oncolytic-based treatments.