Ompc Prp - Search

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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Protein carriers of conjugate vaccines - PubMed Central (PMC)
Merck devised a “bi-molecular” conjugation of PRP to an outer membrane protein complex of N. mening9 thereby making the vaccine “PRP-OMPC.” Cumulatively, this work introduced a new …
Other content from pmc.ncbi.nlm.nih.gov
- Haemophilus influenzae type b conjugate vaccines - PMC
- Outer Membrane Vesicle Vaccine Platforms - PMC
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Drugs.com
https://www.drugs.com › mtm › haemophilus-b-conjugate...
Haemophilus b conjugate (PRP-OMP) vaccine - Drugs.com
What Is Haemophilus B Conjugate (Prp-Omp) Vaccine?
This Vaccine Side Effects
Before Taking This Medicine
How Is This Vaccine given?
Haemophilus B Conjugate (Prp-Omp) Vaccine Dosing Information
What Happens If I Miss A dose?
What Other Drugs Will Affect This Vaccine?
Further Information
Haemophilus influenzae type B (Hib) is a bacteria that can cause serious illness, including breathing problems or meningitis. Hib infectionusually affects children and can be fatal. Haemophilus B conjugate (PMP-OMP) vaccine is used to help prevent this disease in infants and children 2 to 71 months of age. The vaccine works by exposing your child t...
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ScienceDirect
https://www.sciencedirect.com › science › article › pii
Protective immune responses against Haemophilus influenzae …
Mar 1, 2021 · Hib capsular polysaccharide, polyribosylribitol phosphate (PRP), is conjugated to Neisseria meningitidis outer membrane protein complex (OMPC). Safety and immunogenicity …
- Author: Marissa B. Wilck, Z. Jin Xu, Jon E. Stek, Michelle G. Goveia, Andrew W. Lee
- Publish Year: 2021
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Protective immune responses against Haemophilus influenzae type b elicited by a fully-liquid DTaP-IPV-Hib-HepB vaccine (VAXELIS™)
Background DTaP-IPV-Hib-HepB is a fully-liquid, hexavalent combination vaccine (Vaxelis™) approved for vaccination against diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, and invasive disease due to Haemophilus influenzae type b (Hib). Hib capsular polysaccharide, polyribosylribitol pho...
Published: 2021/03/01
Cited By: 0
Keywords: Safety; Im…
PubMed
Anti-PRP antibody levels after a primary series of PRP-OMPC and persistence of antibody titres following primary and booster doses
The Haemophilus influenzae capsular polysaccharide-outer membrane protein conjugate, PRP-OMPC (PedvaxHIB) elicits very good antibody responses in infants > or = 2 months of age after the first dose. Increasing age at time of first vaccination correlates with higher antibody responses. Anti-PRP respo...
Author: G B Calandra
Published: 1993
Keywords: National In…
ScienceDirect
Anti-PRP antibody levels after a primary series of PRP-OMPC and persistence of antibody titres following primary and booster doses
The Haemophilus influenzae capsular polysaccharide-outer membrane protein conjugate, PRP-OMPC (PedvaxHIB) elicits very good antibody responses in infants ≥ 2 months of age after the first dose. Increasing age at time of first vaccination correlates with higher antibody responses. Anti-PRP responses ...
Published: 1993/01/01
Cited By: 0
Keywords: Haemophil…
ScienceDirect
Haemophilus influenzae type b conjugate vaccine stability: catalytic depolymerization of PRP in the presence of aluminum hydroxide
The structural stability of the Haemophilus influenzae type b (Hib) capsular polysaccharide, polyribosylribitolphosphate (PRP) in an aluminum hydroxide adsorbed, polysaccharide–protein conjugate vaccine was monitored using modifications of an HPLC assay developed by Tsai et al. [Tsai C-M, Gu X-X, By...
Published: 1999/03/05
Cited By: 0
Page Count: 10
PubMed
A combined liquid Hib (PRP-OMPC), hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine: controlled studies of immunogenicity and reactogenicity
We evaluated the immunogenicity and reactogenicity of a new liquid pentavalent combination vaccine, which incorporates a diphtheria, tetanus and whole-cell pertussis vaccine (DTP) with Hib (PRP-OMPC) and hepatitis B vaccine (HB), in a series of three studies involving 2156 infants. The vaccination s...
Author: T Nolan
Published: 2001/02/28
Keywords: National In…
PubMed
Immunogenicity of a Haemophilus influenzae polysaccharide-Neisseria meningitidis outer membrane protein complex conjugate vaccine
Polysaccharide-protein conjugate vaccines made with different carriers vary in their ability to elicit antipolysaccharide IgG antibody responses in young infants and an adult mouse model, suggesting that the carrier proteins used in the conjugate vaccines differ in their ability to act as carriers, ...
Author: J J Donnelly
Published: 1990/11/01
Keywords: National In…
PubMed
Reactivity characterization of bromoacetyl derivatized polyribosylribitol polysaccharide in Haemophilus influenzae type b for PedvaxHIB® by NMR spectroscopy
PedvaxHIB® is a highly purified capsular polysaccharide (polyribosylribitol phosphate or PRP) of Haemophilus influenzae type b (Hib) that is covalently linked to an outer membrane protein complex (OMPC) of Neisseria meningitidis pediatric vaccine. This Hib protein conjugate vaccine is very effective...
Author: Richard R Rus…
Published: 2021 Dec
Keywords: Haemophil…
PubMed
Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity
Conjugate vaccines consisting of the capsular polysaccharide (PS) of Haemophilus influenzae type b (Hib) covalently linked to carrier proteins, unlike pure PS, are immunogenic in infants and have significantly reduced Hib infections in the United States, but require multiple doses to induce protecti...
Author: Eicke Latz
Published: 2004/02/15
Keywords: National In…
PubMed
https://pubmed.ncbi.nlm.nih.gov
Anti-PRP antibody levels after a primary series of PRP-OMPC and ...
The Haemophilus influenzae capsular polysaccharide-outer membrane protein conjugate, PRP-OMPC (PedvaxHIB) elicits very good antibody responses in infants > or = 2 months of age …
CDC
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HibVax Preliminary Analyses
Feb 28, 2024 · Post-dose 1 anti-Hib GMCs following Vaxelis® met the pre-specified criteria for non-inferiority. Including Vaxelis® among the vaccines with a preferential recommendation …
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ScienceDirect
https://www.sciencedirect.com › science › article › pii
Anti-PRP antibody levels after a primary series of PRP-OMPC and ...
Jan 1, 1993 · The Haemophilus influenzae capsular polysaccharide-outer membrane protein conjugate, PRP-OMPC (PedvaxHIB) elicits very good antibody responses in infants ≥ 2 …
People also ask
Can a PRP assay be used to monitor conjugated PRP content?
This study, built on the previous work of Tsai et al. , shows quite clearly that the assay can be used to determine the total PRP content in all Hib vaccines and may well be adaptable to monitor conjugated PRP content in these products, both on release of the product and as a stability-indicating assay.
Haemophilus influenzae - ScienceDirect
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What is the MRCP procedure and how does it work?
Dr. Rinta M Babu
MBBS · 2 years of exp
MRCP procedure is used for liver, pancreas and gall bladder conditions. It is a very advanced procedure done by radiologist, by infusing a dye through the veins and visualizing the liver and look for the cause of jaundice, cancer of liver and pancrease.
Q&A: Mrcp Procedure
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What is a reference standard for measuring PRP concentrations?
A production lot of aluminum hydroxide-adsorbed PRP–OMPC (15 μg PRP/ml) was used as the reference standard for measuring PRP concentrations. The standard curve was prepared such that constant amounts of aluminum, citrate and phosphate were maintained.
Haemophilus influenzae - ScienceDirect
sciencedirect.com
How do you measure total PRP content?
For measurement of total PRP content, aluminum hydroxide adsorbed PRP–OMPC samples were diluted to a target concentration of 15 μg PRP/ml and then subjected to aluminum hydroxide dissolution (i.e. sample brought to a final concentration of 3% (w/v) sodium citrate, 50 mM sodium phosphate, pH 7.2, and incubated at 95°C for 3 min).
Haemophilus influenzae - ScienceDirect
sciencedirect.com
Does PRP induce a memory effect in children?
PRP is a T-cell independent immunogen and thus by itself is not capable of inducing a immune memory effect in children less than about two-years old (Ref. and references therein).
Haemophilus influenzae - ScienceDirect
sciencedirect.com
How accurate is a PRP assay?
Results of the validation studies show this assay to have comparable operating characteristics for both sample matrices and to be superior to previously used chemical colorimetric and immunological methods for precise and accurate analysis of PRP content in these vaccine products. A summary of the validation results are provided in Table 1.
Haemophilus influenzae - ScienceDirect
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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Haemophilus influenzae type b conjugate vaccines - PMC
A comparison of three different Hib conjugates (HbOC, PRP-OMP and PRP-T) given at 2, 3 and 4 months showed a priming response for all three vaccines when a polysaccharide ‘booster’ was …
ScienceDirect
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Haemophilus influenzae type b conjugate vaccine stability: …
Mar 5, 1999 · As applied to products containing PRP conjugated to the outer membrane protein complex (OMPC) from Neisseria meningitidis, this assay allows direct measurement of the …
PubMed
https://pubmed.ncbi.nlm.nih.gov
A combined liquid Hib (PRP-OMPC), hepatitis B, diphtheria
Feb 28, 2001 · We evaluated the immunogenicity and reactogenicity of a new liquid pentavalent combination vaccine, which incorporates a diphtheria, tetanus and whole-cell pertussis …
Oxford Academic
https://academic.oup.com › jimmunol › article
Effect of Haemophilus influenzae polysaccharide outer membrane …
Dec 15, 1992 · We propose that this unique property may confer increased immunogenicity to PRP-OMPC through macrophage activation and cytokine release. Furthermore, the effect on …
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