Jul 28, 2022 · Synthetic unmethylated CpG oligodeoxynucleotide (ODN), a commonly used agonist for TLR9, stimulate various antigen-presenting cells in the tumour microenvironment, …

CpG ODNs are recognized by the Toll-like receptor 9 (TLR9), which is expressed on human B cells and plasmacytoid dendritic cells (pDCs), thereby inducing Th1-dominated immune …

ODN 2006 (ODN 7909) is a Class B CpG oligonucleotide (ODN) with a preference for the human Toll-like receptor 9 (TLR9). It is a short synthetic single-stranded DNA molecule containing …

Jun 1, 2006 · Excessive doses of CpG ODN can induce a lethal systemic inflammatory response syndrome in rodents that is rodent-specific, apparently resulting from their broader distribution …

Stimulatory CpG ODNs are internalized and activate the endosomal receptor TLR9. Activation of TLR9 triggers NF-κB- and interferon regulatory factor (IRF)-mediated pro-inflammatory …

Dec 2, 2016 · We report interim Phase 1/2 data of combination XRT and SD-101, a synthetic class C CpG-ODN TLR9 agonist, selected for the strong induction of type I interferon. …

Exogenous CpG‐oligodeoxynucleotides (ODN) stimulate TLR9 mediate innate immune signalling, and have been used to study the pathogenesis of sterile inflammation.

Dec 12, 2023 · In their current work, Pollak and colleagues 1 made an important contribution with regard to immunostimulatory properties of antisense oligodeoxynucleotides (ODNs), which as …

CpG Oligodeoxynucleotides (ODNs) are established TLR9 ligands; however, their functional responses in CD4+ T cells are believed to be independent of TLR9 and MyD88. We studied …

Apr 15, 2021 · Introduction: Toll-like receptor-9(TLR9) can recognize the foreign unmethylated CpG DNA, and thus intrigue a strong Th1 response which plays a crucial role in the innate and …