The OCT measurements that are clinically meaningful for MS are peri-papillary retinal nerve fiber layer (RNFL) thickness, ganglion cell layer and inner plexiform layer (GCLIPL) thickness, and macular cube volume.

Originally developed for retinal diseases and glaucoma, optical coherence tomography (OCT) allows direct visualization and measurement of the optic nerve head topography, and of retinal nerve fiber layer (RNFL) thickness with micron-scale resolution (Sakata et al., 2009).

Optical coherence tomography has contributed to greater insights into the pathophysiology of MS. Loss of RNFL and GCIPL thickness correlates with clinical and paraclinical parameters such as biomarkers, visual function, disability and magnetic resonance imaging in MS.

Based on OCT studies in MS, RNFL thickness is reduced significantly among patients (92 µm) versus controls (105 µm), and is particularly reduced in MS eyes with a history of ON (85 µm).

Optical coherence tomography (OCT) is a new method that could aid analysis of neurodegeneration in multiple sclerosis (MS) by capturing thinning of the retinal nerve fibre layer (RNFL).

Interpretation of OCT in MS Care. OCT processing software automatically calculates the average thickness and thickness by sector of the RNFL, GCIPL, and macular cube with comparison to age-matched controls as seen in Figure 3 where all components of an OCT report are detailed.

Optical coherence tomography (OCT) is a new method that could aid analysis of neurodegeneration in multiple sclerosis (MS) by capturing thinning of the retinal nerve fibre layer (RNFL).

Results: We found that significant average and quadrant RNFLT loss is detectable by OCT in both MS and GA patients compared to healthy controls (p<0.01). The age- and gender adjusted average and quadrant RNFLT did not differ significantly between MS and GA patients (p>0.05).

Jun 2, 2011 · Following an initial episode of optic neuritis, OCT can detect axonal loss as a thinning of the RNFL, occurring mainly in the first three to six months (Figure 2).

Optical coherence tomography (OCT) revealed changes in all RNFL thicknesses in both groups. In the MS group, changes were detected in average thickness and in the mean deviation using the GDx-VCC nerve fiber analyzer (Laser Diagnostic Technologies, San Diego, CA) and in the P100 latency of visual evoked potentials; no changes were detected in ...