Vascularized PEDs associated with type 1 (sub-RPE) neovascularization and wet AMD, in contrast, have a greater risk of vision loss. Fibrovascular PED is a subset of occult choroidal neovascularization (CNV). In eyes with AMD, it is not uncommon …

Jun 15, 2022 · Fluid at any level on OCT, including intraretinal (Figure 6), subretinal (Figure 2E and 3), and subRPE (serous PED, Figure 4) is suggestive of active exudative AMD. With OCT, fluid is hyporeflective or dark, and this imaging is superior to ophthalmoscopy in …

Wet AMD leads to intraretinal fluid (IRF) and subretinal fluid (SRF) accumulation. The choroidal neovascular membrane (CNV) can be visualized. This is an OCT of a pigment epithelial detachment (PED) in wet AMD with some adjacent subretinal fluid (SRF) and an overlying area of focal intraretinal fluid (IRF).

Dec 1, 2014 · OCT shows all the abnormalities—irregular PEDs, subretinal fluid, and intraretinal exudates—but not as specifically as with ICGA. “OCT is supportive of a diagnosis, but not specific to it,” Dr. Goldman said. Dr. Ferrara noted that spectral-domain OCT (SD-OCT) may reveal the polypoidal lesion, if the examiner is looking for it.

Retinal pigment epithelial detachment (PED) is a common manifestation in both dry and wet types of age-related macular degeneration (AMD). PEDs often result in loss of vision by either atrophy or choroidal neovascularization.

Clinically, PEDs appear as domed elevations of the RPE layer and may be associated with other signs of AMD, including drusen, overlying RPE hyperpigmentation, subretinal fluid, or subretinal hemorrhage. On OCT imaging, a PED is identified when a space is formed between the RPE and Bruch’s membrane.

Findings such as intraretinal fluid (IRF), subretinal fluid (SRF), pigment epithelial detachment (PED), and subretinal hyperreflective material (SHRM) on OCT can be used to monitor disease activity and determine when to initiate intravitreal injections and when to follow up with patients. 1

The cross-sectional OCT (corresponding to the dashed white line on the ICGA) transects the polypoidal lesion (C). A sharp-peaked PED with a sub-RPE ring-like structure (asterisk) corresponds to the focal hyperfluorescent nodule on ICGA. The PED is notched and multilocular.

Jan 15, 2023 · OCT-A has brought about new categorization of MNV called subclinical or nonexudative MNV. This type of MNV presents as a PED that is often shallow and elongated. There is minimal or no sign of subretinal or intraretinal fluid on the OCT, but the PED is harboring MNV that is evident on OCT-A.

Time-Domain vs. Spectral-Domain OCT in AMD The new spectral-domain (SD) OCT devices include a spectrometer in the receiver that analyzes the spectrum of reflected light on the retina and transforms it into information about the depth of the structures according to …