Occludin is a transmembrane protein that regulates the permeability of epithelial and endothelial barriers. It was first identified in epithelial cells as a 65 kDa integral plasma-membrane protein localized at the tight junctions. [5] .

Jul 13, 2007 · Occludin is a 65 kD transmembrane protein localized to TJs which anchors ZO-1 and ZO-2 proteins and the plasma membranes of adjacent cells . Occludin is present in large amounts in brain endothelial cells, being undetectable in non-neuronal endothelia .

Apr 25, 2005 · The structure of occludin, including its gene splice variants and protein essential components have been elucidated. Phosphorylation/dephosphorylation plays a major role in regulation of occludin and TJ.

Occludin is a 65-kDa phosphoprotein that is an integral component of tight junctions. It plays a crucial role in forming the paracellular barrier between neighboring cells and is associated with ZO proteins, regulating paracellular permeability. AI generated …

Feb 18, 2023 · Occludin, the first transmembrane protein identified in TJs, has received intense research interest because numerous in vitro studies have suggested its importance in maintaining BBB integrity.

Apr 25, 2005 · Strategies to prevent and/or reverse occludin downregulation may be an important therapeutic target. 1. Introduction and discovery. Tight junctions, adherens junctions, gap junctions and desmosomes are the four types of cell–cell junctions that occur in vertebrates.

Occludin knock down causes an increase in paracellular flux of macromolecules. In the following studies, the effect of occludin depletion on transepithelial permeation of increasing molecular size paracellular probes was examined.

This study suggests that the occludin expression is highly correlated to the development of PTBE in brain tumors and it might be a prognostic indicator for patient survival. Keywords: Occludin, Peritumoral brain edema, Brain neoplasms, Survival rate. INTRODUCTION

Occludin, a 65-kDa tetraspan integral membrane protein, contributes to TJ stabilization and optimal barrier function.

Sep 30, 2020 · Occludin is a key structural component of the blood-brain barrier (BBB) that has recently become an important focus of research in BBB damages. Many studies have demonstrated that occludin could regulate the integrity and permeability of the BBB.