Dec 29, 2024 · The +1 PRF of OAZ1 mRNA is stimulated by polyamines, serving as a critical feedback mechanism in polyamine synthesis regulation. When polyamine levels are elevated, …

Ornithine decarboxylase antizyme is an enzyme that in humans is encoded by the OAZ1 gene. [5][6][7] Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first …

Feb 1, 2024 · The hypusination of eIF5A is specifically required for +1 PRF at the shifty site derived from the ornithine decarboxylase antizyme 1 (OAZ1) in Saccharomyces cerevisiae. …

Jan 24, 2019 · Programmed -1 ribosomal frameshifting (-1PRF) is a widely used translation recoding mechanism. HIV-1 expresses Gag-Pol protein from the Gag-coding mRNA through …

Aug 30, 2007 · Our results showed that the OAZ1 +2222A/G polymorphism is consistently associated with all the 3 phenotypes, suggesting an involvement of the polyamine pathway in …

Jul 12, 2006 · The interplay between polyamine concentration and frameshifting acts as a homeostatic mechanism to maintain appropriate polyamine concentration in the cell. The S. …

Ornithine decarboxylase antizyme 1 (OAZ1) is an antizyme targeting ornithine decarboxylase for degradation, subsequently inhibiting polyamine production to prevent cell proliferation. OAZ1 …

Identified the OAZ1+2222A/G polymorphism as a potential genetic marker of vascular events. Ornithine decarboxylase antizyme 1 enhances the ability of UM1 human oral squamous …

Jan 28, 2024 · Although viral-like −1PRF has been reported in the paternally expressed gene PEG10 derived from retrotransposons , one well-recognized case in eukaryotic genes is the …

Sep 20, 2018 · Interestingly, a few genes that display large drop-off are known examples of PRF. For instance, both OAZ1 and OAZ2 undergo controllable +1 PRF, allowing synthesis of …