Nov 2, 2018 · Co-carriage of OXA-1, a penicillinase with weak affinity for inhibitors, is a major correlate of resistance to piperacillin/tazobactam and co-amoxiclav in E. coli and is commonly …

Sykes and Matthew (7) identified three distinct oxacillinases, named OXA-1, OXA-2, and OXA-3. The first two possessed a characteristic shared by most of the members of this class, in that …

Prevalence of OXA-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see …

Feb 1, 2019 · Co-carriage of OXA-1, a penicillinase with weak affinity for inhibitors, is a major correlate of resistance to piperacillin/tazobactam and co-amoxiclav in E. coli and is commonly …

Mar 19, 2014 · The present study deals with characterizing antimicrobial resistance pattern among septicemia causing K. pneumoniae and the prevalence of inhibitor resistant OXA-1 β …

Background: OXA-1 and OXA-24 are class D β-lactamases that resist clinically used inhibitors. Results: Spectroscopic methods and kinetic measurements show that penem drug candidates …

ESKAPE pathogens are the leading cause of nosocomial infections. The Global Priority List of WHO has categorized ESKAPE as priority 1 and 2 pathogens. Even though several …

Until now, 24 Ambler class D enzymes, named OXA-1 to OXA-22, AmpS and LCR-1, have been characterised, either by sequence and/or by biochemical analyses, but for none of them a …

Jun 16, 2008 · We show that these novel penem inhibitors inactivate the OXA-1 β-lactamase by forming a long-lived acyl enzyme. The antimicrobial activities of penems 1 and 2 combined …

Mar 21, 2022 · The narrow spectrum OXA-1 β-lactamase enzyme was present in 42.6% (286/671) of isolates. OXA-1 was detected in 66.3% (277/418) of isolates with a CTX-M-15 …