We used somatic cell nuclear transfer (SCNT) to generate a mouse from the nucleus of an IgG1 + ovalbumin-specific B cell. The resulting OBI mice show generally normal B-cell development, …

Feb 10, 2014 · OB1 transnuclear B cells express an IgG1 B cell receptor (BCR) specific for ovalbumin (OVA), the epitope of which can be mimicked using short synthetic peptides to …

May 3, 2022 · Using αDEC205-OVA to differentially deliver OVA peptides to GC B cells on the basis of DEC205 allelic copy number, we find DEC205 +/+ B cells take up 2-fold more antigen …

Oct 1, 2008 · Here, we targeted ovalbumin (OVA) to B cells via CD19 and found that a single low dose of anti–CD19-OVA conjugates, but not isotype mAb-OVA, stimulated augmented CD4 …

MHC I–restricted epitopes of chicken ovalbumin (OVA) were originally identified using CD8+ T cells as probes. Here, using bioinformatics tools, we identify 4 additional epitopes in OVA in …

May 31, 2023 · Here we show that a single intradermal vaccination with the adjuvant double mutant heat-labile toxin (dmLT) induces a robust endogenous, vaccine-specific, isotype …

Mar 23, 2018 · To define the capacity of tetramers to identify antigen-specific B cells, we probed the inguinal lymph nodes (iLN) of C57BL/6 mice immunized subcutaneously with OVA and …

Oct 14, 2014 · Thus, OVA-NPs might exert their adjuvant action on B cells, and they represent a promising potential vaccine for generating both IgG1 and IgG2a/IgG2b antibody responses …

Using unique tetramers, we traced natural autoreactive B cells (C1-B) specific for a defined triple-helical epitope on collagen type-II (COL2), constituting a sizeable fraction of the...

Sep 12, 2023 · Here, we developed a new synthetic circuit that was implemented in B cells upon lentiviral vector transduction. This synthetic circuit encodes a sensor (i.e., a B cell receptor …