Mar 13, 2017 · We propose that targeted blockade of the STAT3/SMAD3 axis in tumor cells may represent a novel therapeutic approach to prevent the plasticity required for metastatic progression and tumor...

Dec 10, 2022 · Deregulation of STAT3 is an oncogenic factor that promotes tumorigenesis and epithelial-to-mesenchymal transition (EMT) in various cancers. Oncostatin M (OSM), a pleiotropic cytokine, induces STAT3 activation, exacerbating cervical cancer.

Jun 5, 2024 · Using ectopic expression and knockdown approaches, we proved that OSMR directly regulates ITGAV and ITGB3 gene expression through STAT3 activation. Notably, targeting OSMR using anti-OSMR human...

Dec 10, 2022 · Oncostatin M (OSM) induces Signal Transducer and Transcription 3 (STAT3) activation, exacerbating cervical cancer. The molecular mechanism by which the OSM-STAT3 axis regulates tumor-progression-related genes in cervical cancer is not well understood.

Apr 11, 2011 · These data indicate OSM stimulation of human and canine OSA cells induces STAT3 activation, thereby enhancing the expression/activation of MMP2 and VEGF, ultimately promoting invasive behavior and tumor angiogenesis.

Oct 15, 2021 · SIGNIFICANCE: This study uncovers a role for OSMR in promoting ovarian cancer cell proliferation and metastasis by activating STAT3 signaling and demonstrates the preclinical efficacy of antibody-based OSMR targeting for ovarian cancer treatment.

OSM has also been shown to be overexpressed in cSCC patients, and overexpression of OSM in vitro and shown to induce STAT3 and ERK phosphorylation and activation, as well as increased proliferation and migratory capacity in vitro (194–196).

While multiple signal transduction pathways can result in phosphorylation of STAT3, stimulation of the cytokine receptor gp130 through either IL-6 or Oncostatin M (OSM) is the most common mechanism through which STAT3 is activated.

Jan 1, 2021 · OSM is a tumor site dominant cytokine associated with the immunopathogenesis of numerous cancers. STAT3 acts as the main transcription factor in the OSM signaling pathways. OSM has conflicting consequences that can lead to the progression or suppression of tumors.

Oct 26, 2021 · The administration of STAT3 inhibitors effectively suppressed the OSM-mediated biological effects, which proved the key role of STAT3 in OSM signaling. Taken together, our study provides a comprehensive understanding with regard to the tumor progression under the regulation of OSM.