Mar 30, 2025 · OPTN (Optineurin) is a Protein Coding gene. Diseases associated with OPTN include Glaucoma, Primary Open Angle and Amyotrophic Lateral Sclerosis 12 With Or Without Frontotemporal Dementia.

Optineurin is a protein that in humans is encoded by the OPTN gene. [5][6][7] This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma.

Mutations in the OPTN gene affect the neuroinflammatory response through loss of function. Additionally, OPTN plays a crucial role in inhibiting NF-κB activity, which is essential for the innate immune response.

Optineurin was a logical candidate gene on the basis of its physical location on chromosome 10 and its expression in retina. Vittitow and Borras (2002) studied the effect of glaucomatous insults on the expression of OPTN in human eyes maintained in organ culture.

Sep 13, 2021 · Optineurin (OPTN) is a conserved autophagy receptor with little understanding of its role in neurotropic viral infections. We show that OPTN selectively targets HSV-1 tegument protein, VP16, and...

Feb 8, 2025 · OPTN gene is the causative gene for POAG (primary open-angle glaucoma) and suggest a different mutation pattern of OPTN in Chinese than in whites. mGLuR1a signaling is attenuated by the huntingtin-binding protein optineurin

Optineurin is a cytosolic protein encoded by the OPTN gene. Mutations of OPTN are associated with normal tension glaucoma and amyotrophic lateral sclerosis. Autophagy is an intracellular degradation system that delivers cytoplasmic components to the ...

Oct 27, 2021 · Here we show that OPTN is upregulated in human and mouse DC maturation, and that deletion of Optn in mice via CD11c -Cre attenuates DC maturation and impairs the priming of CD4 + T cells, thus...

Feb 5, 2024 · This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma.

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma.