Mar 30, 2025 · OPRM1 (Opioid Receptor Mu 1) is a Protein Coding gene. Diseases associated with OPRM1 include Colchicine Resistance and Substance Dependence. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and Gene expression (Transcription).

Three variants of the μ-opioid receptor are well characterized, though reverse transcription polymerase chain reaction has identified up to 10 total splice variants in humans. [15][16][17] More is known about the μ 1 opioid receptor than the other variants. TRIMU 5 is a selective agonist of the μ 2 receptor. [18]

The OPRM1 gene provides instructions for making a protein called the mu (μ) opioid receptor. Opioid receptors are part of the endogenous opioid system, which is the body's internal system for regulating pain, reward, and addictive behaviors.

Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to mu-opioidergic cell types. Cell-type specific molecular architecture for mu opioid receptor function in pain and addiction circuits.

In human populations, a commonly investigated SNP (rs1799971) occurs in exon 1 of the μ-opioid receptor gene (OPRM1), in which an adenine to guanine substitution (A118G) exchanges an asparagine for an aspartic acid at a putative N-glycosylation site (N40D).

Feb 8, 2025 · Natural variation in the μ-opioid gene OPRM1 predicts increased pain on third day after thoracotomy. Ochroch EA, Vachani A, Gottschalk A, Kanetsky PAOchroch EA, et al. Clin J Pain, 2012 Nov-Dec. PMID 22209801; Uniform assessment and ranking of opioid μ receptor binding constants for selected opioid drugs.

Mar 11, 2024 · We identified 47 interactions stronger in high-survival RGCs, likely mediating neuroprotective effects. We validated one identified target, the μ-opioid receptor (Oprm1), to be...

The OPRM1 gene provides instructions for making a protein called the mu (m) opioid receptor. Opioid receptors are part of the endogenous opioid system, which is the body' s internal system for regulating pain, reward, and addictive behaviors.

Jan 4, 2025 · Title: Variation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment. Accumbal mu-opioid receptors and salt taste-elicited hedonic responses in a rodent model of prenatal adversity, and their correlates using human functional genomics.

The mu-opioid receptor, encoded by the OPRM1 gene, is the primary receptor for the endogenous opioid peptide b-endorphin, but is also the site at which exogenous opioids including morphine and heroin bind (1,2).