Mar 30, 2025 · NTN1 (Netrin 1) is a Protein Coding gene. Diseases associated with NTN1 include Mirror Movements 4 and Mirror Movements 1. Among its related pathways are Netrin-1 signaling and Nervous system development. An important paralog of this gene is NTN3.

Netrin-1 is a protein that in humans is encoded by the NTN1 gene. [5][6] Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development.

Nov 27, 2024 · Gene target information for NTN1 - netrin 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Jan 25, 2025 · NTN1 exhibits substantial clinical utility as a prognostic marker and indicator of immune response across various tumor types. This comprehensive analysis provides insights into its potential implications in pan-cancer research.

Jun 28, 2024 · Netrin-1 (NTN1) was found up-regulated in nerve stump after peripheral nerve injury (PNI). Herein, we demonstrated that NTN1-high endothelial cells (NTN1+ECs) were the critical component of vascular niche, fostering angiogenesis, axon regeneration, and repair-related phenotypes.

Jan 27, 2021 · NTN1–NEO1 represents a novel intercellular and non-cell autonomous signalling network by which NTN1 produced by perivascular niches binds to HSCs to fine-tune HSC dynamics, in particular cell...

Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor. Netrin-1 protects blood-brain barrier (BBB) integrity after cerebral ischemia-reperfusion by activating the Kruppel-like factor 2 (KLF2)/occludin pathway.

Jul 8, 2015 · In various somatic cells, we found that reprogramming is accompanied by a transient transcriptional repression of Netrin-1 mediated by an Mbd3/Mta1/Chd4-containing NuRD complex....

The axonal guidance cue netrin-1 serves a critical role in neural circuit development by promoting growth cone motility, axonal branching, and synaptogenesis. Within the adult mouse brain, expression of the gene encoding (Ntn1) is highly enriched in ...

Apr 18, 2023 · Netrin-1 (Ntn1) is a secreted ligand critical for vessel and neuronal guidance. Here, we demonstrate that Ntn1 is expressed by stromal progenitors in the developing kidney, and conditional deletion of Ntn1 from Foxd1+ stromal progenitors (Foxd1GC/+; Ntn1fl/fl) results in hypoplastic kidneys that display extended nephrogenesis.