Feb 20, 2020 · In the present study, we examined nuclear factor erythroid 2-related factor 2 (Nrf2)- and mitogen-activated protein kinases (MAPKs)-mediated oxidative stress pathways in zebrafish embryos upon exposure to PFOS.

Antioxidant SFN supplementation and p38 MAPK inhibitor provided protection against TCE-mediated inflammation and autoimmunity by modulating Nrf2/MAPK pathways. Highlights. TCE- mediated dysregulation of Nrf2 signaling contributes to disease progression

Activation of Nrf2 can also be triggered through MAPK signaling molecules, such as p38 and JNK (32, 33). Besides, protein kinase C (PKC) was shown to phosphorylate the Neh2 structural domain of Nrf2 ( 34 ), leading to dissociation of Nrf2 from its repressor Keap1, thus promoting the transcriptional activity of Nrf2 ( 35 ).

May 20, 2021 · Additionally, cyclin-dependent kinase 5 (CDK5) and mitogen-activated protein (MAP) kinase (MAPK) were found to phosphorylate NRF2 at multiple sites within locations that could not be designated as specific structural domains of NRF2. Other phosphorylation modifications of NRF2 are described below.

Aug 14, 2023 · In summary, activation of the MAPK pathway can inhibit ferroptosis by promoting the phosphorylation and nuclear translocation of Nrf2. The MAPK signaling pathway can also regulate ferroptosis by regulating voltage-dependent anion channels (VDAC) between the mitochondria and the cytoplasm .

We have identified multiple serine/threonine residues as major targets of MAPK-mediated phosphorylation. Combined alanine substitution on those residues leads to a moderate decrease in the transcriptional activity of Nrf2, most likely due to …

Jun 15, 2021 · Dysregulation of redox-sensitive nuclear factor (erythroid-derived 2)-like2 (Nrf2), resulting in uncontrolled antioxidant and cytoprotective genes, and pro-inflammatory MAPK signaling pathways could be critical in TCE-mediated disease progression.

Jan 24, 2017 · This study will provide a better understanding of how the copepod P. nana manages microplastic-induced oxidative stress via MAPK/Nrf2 pathways with regard to the adverse outcome pathway (AOP).

4 days ago · Osseous echinococcosis causes severe "osteolytic" changes in the bone tissue of Echinococcus granulosus (E. granulosus) infection sites by promoting the over-differentiation of osteoclasts at the site. Nrf2 is a key regulator of osteoclast differentiation and formation, and this study investigated t …

4 days ago · For in vivo studies, an E. granulosus-infected femoral CE model was established using Nrf2 knockout mice, which exhibited more active osteoclast differentiation in bone tissues than normally infected mice without Nrf2 knockout. The MAPK signalling pathway has been shown to play an important regulatory role in hydatid disease and macrophage ...