We report that Nrf2 modulates the GSH redox state by regulating glutathione reductase (GSR). In response to oxidants, lungs and embryonic fibroblasts (MEFs) from Nrf2-deficient (Nrf2−/−) …

Nov 27, 2019 · One of these mechanisms is the reduction in the intracellular accumulation of cisplatin due to an increase in the thiol-containing protein-mediated inactivation, such as …

Through the coordinated activation of GSH production, utilization, and regeneration, Nrf2 ensures that intracellular levels of reduced GSH are maintained. In addition to the regulation of GSH …

Oct 24, 2023 · Exogenous H 2 S activated the nuclear factor erythroid 2-related factor 2 (Nrf2)/glutathione peroxidase 4 (GPx4)/glutathione (GSH) pathway, suppressed ferroptosis …

Mar 4, 2025 · NRF2 has emerged as a master regulator of cellular homeostasis, orchestrating redox balance, metabolic stability, proteostasis and intracellular iron dynamics — collectively …

Nov 27, 2019 · Thus, the results indicate that NRF2 and glutathione levels figure as important cisplatin resistance biomarkers in lung cancer. Lung cancer patients face a dismal prognosis …

Nov 19, 2020 · The activation of the cellular NRF2 (nuclear factor erythroid 2 like 2) pathway and induction of cytoprotective genes accompanies an increase in ROS levels. A plethora of …

Feb 15, 2009 · We report that Nrf2 modulates the GSH redox state by regulating glutathione reductase (GSR). In response to oxidants, lungs and embryonic fibroblasts (MEFs) from Nrf2 …

Nov 22, 2024 · Our findings indicate that DMF increases levels of glutathione (GSH), glutamate cysteine ligase modifier subunit (GCLM), and nuclear Nrf2 in SH-SY5Y cells. Importantly, DMF …

Nov 9, 2024 · Based on the evidence that NRF2 and GSH are determinants for cisplatin resistance in cell culture of lung cancer lines, we aimed to investigate if this is reflected in the …