Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and ...

Mar 30, 2025 · NRF1 (Nuclear Respiratory Factor 1) is a Protein Coding gene. Diseases associated with NRF1 include Oncocytoma and Skin Carcinoma In Situ. Among its related pathways are Cellular responses to stimuli and Transcriptional activation of …

Sep 6, 2021 · Our findings reveal that the adaptive stress response mechanism mediated by Nrf1 is required for neonatal heart regeneration and confers cardioprotection in the adult heart. Heart disease...

There are a number of molecular regulators that aid NRF1 to fulfill its role as a transcriptional activator of proteasome genes. Fortunately, some of these regulators, such as p97, NGLY1, DDI2, RUVBL1, and TIP60, possess enzymatic activity that can be readily targeted to inactivate the NRF1 pathway.

Nrf1 is a member of the vertebrate Cap`n'Collar (CNC) transcription factor family that commonly contains a unique basic-leucine zipper domain. Among CNC family members, Nrf2 is known to regulate a battery of antioxidant and xenobiotic-metabolizing ...

Overall, Nrf1 acts as a vital player in determining and maintaining robust redox homeostasis by governing mitochondrial homeostasis integrated from multi-hierarchical signaling pathways towards cognate gene regulatory networks.

NRF1 (nuclear respiratory factor-1) also known as alpha-palindrome-binding protein is a transcription factor that binds as a homodimer to the DNA sequence motif YGCGCAYGCGCR, where Y and R indicate a pyrimidine (T/C) or purine (A/G) nucleotide.

Mar 4, 2025 · Gene target information for NRF1 - nuclear respiratory factor 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Sep 15, 2020 · In this Perspective, we track the journey of NRF1 from the ER to the nucleus, with a special focus on the various molecular regulators it encounters along its way.

Nuclear respiratory factor 1 (NRF-1) upregulates the expression and function of reduced folate carrier (RFC) at the blood-brain barrier. Positive regulation of human PINK1 and Parkin gene expression by nuclear respiratory factor 1.