Mar 30, 2025 · NR5A2 (Nuclear Receptor Subfamily 5 Group A Member 2) is a Protein Coding gene. Diseases associated with NR5A2 include Hepatitis B and Hepatitis. Among its related …

In vitro studies on mouse embryos have recently identified the orphan nuclear receptor NR5A2 as a key player at this developmental stage. However, although NR5A2 was initially considered …

The liver receptor homolog-1 (LRH-1) also known as totipotency pioneer factor NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is encoded by the …

Nov 24, 2022 · Gassler et al. discovered that Nr5a2 and potentially related orphan nuclear receptors activate transcription of most ZGA genes in mouse embryos. Nr5a2 binds to …

Feb 26, 2024 · Here, we present a cryo-electron microscopy structure of human NR5A2 bound to a nucleosome. The structure shows that the conserved carboxy-terminal extension (CTE) loop …

Oct 13, 2021 · NR5A2 is a member of NR5A subfamily having four members (Nr5a1–Nr5a4). NR5A2 shows involvement in diverse biological processes like reverse cholesterol transport, …

Feb 14, 2018 · In mouse pancreas cells with only one copy of the Nr5a2 gene, the orphan nuclear receptor NR5A2 undergoes a marked transcriptional shift from differentiation-specific to …

Mar 26, 2024 · Recent studies have elucidated Nr5a2’s role in activating zygotic genes during early mouse embryonic development. Subsequent research, however, reveals that Nr5a2 is …

Nuclear receptor subfamily 5 group A member 2 (NR5A2): role in health and diseases. Nuclear-mitochondrial crosstalk: On the role of the nuclear receptor liver receptor homolog-1 (NR5A2) …

Here, we investigated the role of nuclear receptor (NR) transcription factors (TFs), whose motifs are highly enriched and accessible from the 2-cell (2C) to 8-cell (8C) stages in mouse …