Regulatory Landscapes of Nppa and Nppb | Circulation Research
Jan 7, 2021 · Nppa encodes ANP (atrial natriuretic peptide), whereas Nppb encodes BNP (B-type natriuretic peptide), both hormones secreted by the heart and involved in cardiac …
Structure and function of the Nppa-Nppb cluster locus during …
In this review, we will provide recent insights into the dynamic and complex regulation of Nppa and Nppb during heart development and hypertrophy, and the association of this gene cluster …
Structure and function of the Nppa–Nppb cluster locus during …
In this review, we will provide recent insights into the dynamic and complex regulation of Nppa and Nppb during heart development and hypertrophy, and the association of this gene cluster …
Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb ...
Oct 27, 2020 · ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide), encoded by the clustered genes Nppa and Nppb, are important prognostic, diagnostic, and therapeutic …
Cardiac natriuretic peptides | Nature Reviews Cardiology
May 22, 2020 · Nppb expression relies on the interaction of the promoter with a single upstream enhancer region, where the levels of H3K27 acetylation (H3K27ac) might contribute to Nppb …
Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb ...
Jan 8, 2021 · Coordinated ventricular expression of <i>Nppa</i> and <i>Nppb</i> is controlled in a competitive manner by a shared super enhancer, which is also required to augment stress …
The Impact of Natriuretic Peptides on Heart Development, …
During mammalian heart development, the clustered genes encoding peptide hormones, Natriuretic Peptide A (NPPA; ANP) and B (NPPB; BNP), are transcriptionally co-regulated and …
In this issue of Circulation Research, Man et al7 shed light into how complex regulatory landscapes are orga-nized by dissecting the transcription regulation of the Nppa-Nppb gene …
Identification of a regulatory domain controlling the Nppa-Nppb …
Jun 15, 2016 · The paralogous genes Nppa and Nppb are organized in an evolutionarily conserved cluster and provide a valuable model for studying co-regulation and regulatory …
Regulatory Landscapes of Nppa and Nppb - PMC
Nppa encodes ANP (atrial natriuretic peptide), whereas Nppb encodes BNP (B-type natriuretic peptide), both hormones secreted by the heart and involved in cardiac development, …