NOX4-mediated ROS production can be induced by hypoxia and by stimulation with lipopolysaccharide , insulin , and angiotensin . NOX4 is localized in mitochondria , …

Nox4 is an oddity among members of the Nox family of NADPH oxidases [seven isoenzymes that generate reactive oxygen species (ROS) from molecular oxygen] in that it is constitutively …

Oct 26, 2023 · In cancers, dysregulation of NOX enzymes affects ROS production, leading to redox unbalance and tumor progression. Consequently, NOXs are a drug target for cancer …

Aug 15, 2011 · Here we report that H-RasV12 positively regulates the NADPH oxidase system NOX4-p22 phox that produces H 2 O 2. Knocking down the NADPH oxidase with small …

NADPH Oxidase 4 (NOX4), a member of the NOX family, has emerged as a significant source of reactive oxygen species, playing an important role in tumor cell proliferation, apoptosis, and …

Increased generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of a variety of diseases such as cardiovascular diseases and cancer. NADPH oxidase (Nox), a …

Jun 23, 2023 · Studies suggest that Nox4-derived ROS in mitochondria could lead to mitochondrial dysfunction by opening the permeability transition pore, leading to cytochrome c …

Oct 19, 2017 · We provide evidence that NOX4-derived reactive oxygen species (ROS) inhibits P300/CBP-associated factor (PCAF)-dependent acetylation and lysosomal degradation of the …

Jun 6, 2008 · The principal finding of this study is that endothelial Nox4, an endogenous source of ROS in HAECs, is localized to the ER and appears involved in the regulation of another ER …

Jun 27, 2021 · Here, our findings demonstrated that TGF-β1 upregulated NOX4 expression accompanied by reactive oxygen species (ROS) through Smad-dependent signaling and then …