NOX1 is expressed in pancreatic β-cells and plays an important role for ROS production during glucose-stimulated insulin secretion . A further connection between the glucose-sensing mechanism and NOX1 is observed in C2C12 cells that show a NOX1-dependent glucose sensing pathway for selective phosphorylation of p70S6k.

Jun 1, 2021 · The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first identified in the membrane of phagocytic cells. For many years, its only known role was in immune defense, where its ROS production leads to the destruction of …

NOX1 deficiency plus TNFα stimulation contribute to colitis through dysregulation of the stem cell niche and altered cell differentiation, enhancing basal lymphoplasmacytosis. Our findings prioritise ROS modulation for future therapies.

Oct 22, 2024 · In this study, we explore the role of NOX1 and ROS through direct ex vivo studies of single cell UC transcriptomics (scRNAseq) and in vitro and in vivo murine studies. We show that under a variety of colonoid differentiation conditions, TNFα induced ROS secretion is dependent upon NOX1.

In colon, NOX1 may accelerate the adhesion of LPS-stimulated cancer cells through a mechanism in which TLR-4-mediated activation of NF-κβ leads to increased activation of NOX and a higher level of ROS, promoting the phosphorylation of Akt .

Together with the phagocyte NADPH oxidase itself (NOX2/gp91 (phox)), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS).

Oct 2, 2018 · We found that ROS produced by NOX1 drive the expression of LCN-2 in human epithelial cells co-stimulated by TNFα and IL-17, and that the underlying mechanisms involve a p38MAPK-JNK/NOXO1/IkBζ...

Dec 6, 2017 · Here, we show a role for nitric oxide synthase (iNOS)- and NOX1-produced ROS in maintaining homeostasis of the gut microbiota. In vivo imaging revealed distinctly high levels of ROS in the...

Sep 14, 2024 · The data presented herein suggests that ROS formation by the Nox1-centered NADPH oxidase is dependent on the concentration of NoxO1. A surplus of NoxO1 has been observed to exert control over the activity of the complex in accordance with a …

Feb 13, 2019 · PDIA1 is known to support vascular Nox1 NADPH oxidase expression/activation. Since deregulated reactive oxygen species (ROS) production underlies tumor growth, we proposed that PDIA1 is an...