Neurogenic locus notch homolog protein 3 (Notch 3) is a protein that in humans is encoded by the NOTCH3 gene. [5][6] This gene encodes the third discovered human homologue of the …

The NOTCH3 gene provides instructions for making a protein with one end (the intracellular end) that remains inside the cell, a middle (transmembrane) section that spans the cell membrane, …

Mar 30, 2025 · NOTCH3 (Notch Receptor 3) is a Protein Coding gene. Diseases associated with NOTCH3 include Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And …

Through our preliminary genetic and proteomic analysis of the Notch3 protein (Dr Baumann group), we are aware of a series of point mutations of the Notch3 protein which lead to loss of …

Notch3 is one of four mammalian Notch proteins, which act as signalling receptors to control cell fate in many developmental and adult tissue contexts. Notch signalling continues to be …

This review article focuses on the Notch3 gene subtype, summarizing its role in cancer, possible mechanisms of its action, and current cancer treatment strategies targeting Notch3 signaling. …

Mar 23, 2020 · Here we discuss the distinctive roles of Notch3 in development, health and disease, different views as to the underlying mechanisms of its activation and misregulation in …

May 18, 2021 · In general, we have identified a positive correlation between Notch3 and PTEN in breast cancer and confirmed a role for the Notch3-PTEN axis in inhibiting tumor proliferation …

The NOTCH3 gene encodes a single pass transmembrane protein belonging to an evolutionarily conserved NOTCH receptor family (see, e.g., NOTCH1; 190198). After ligand binding, the …

Identifying disease-causing variants within the NOTCH3 gene known to be associated with CADASIL and NOTCH3-related disorders, allowing for predictive testing of at-risk family …